TDG Products
(Thymine-DNA Glycosylase (TDG))
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The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008].
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Featured TDG Categories
TDG Antibodies
High quality antibodies with extensive validation data.
TDG ELISA Kits
Reliable ELISA kits for a wide range of species.
TDG Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TDG Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7153379
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF, ICC
Validations
- (2)
Cat. No.
ABIN6258811
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, FACS
Validations
- (2)
Cat. No.
ABIN390559
Quantity
400 μL
Datasheet
Datasheet
Recommended TDG ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959949
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1134027
Quantity
96 tests
Datasheet
Datasheet
Recommended TDG Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN1098673
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322426
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1785499
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our TDG products
: "Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability." in: Genome biology, Vol. 19, Issue 1, pp. 37, (2018) (PubMed).: "A G-quadruplex-selective luminescent probe with an anchor tail for the switch-on detection of thymine DNA glycosylase activity." in: Biosensors & bioelectronics, Vol. 86, pp. 849-57, (2016) (PubMed).
: "TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1." in: Oncogene, Vol. 36, Issue 16, pp. 2202-2214, (2016) (PubMed).
: "Base excision repair of tandem modifications in a methylated CpG dinucleotide." in: The Journal of biological chemistry, Vol. 289, Issue 20, pp. 13996-4008, (2014) (PubMed).
: "Crystal structure of thymine DNA glycosylase conjugated to SUMO-1." in: Nature, Vol. 435, Issue 7044, pp. 979-82, (2005) (PubMed).
: "Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover." in: The EMBO journal, Vol. 21, Issue 6, pp. 1456-64, (2002) (PubMed).
: "Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase." in: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12767-74, (1996) (PubMed).
: "Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 5, pp. 1642-6, (1994) (PubMed).
Synonyms and alternative names related to TDG
thymine DNA glycosylase (TDG), thymine DNA glycosylase, tandem duplicate 1 (tdg.1), putative g/t mismatch-specific thymine DNA glycosylase (Smp_149220), G/T mismatch-specific thymine DNA glycosylase (Tsp_05734), thymine DNA glycosylase S homeolog (tdg.S), thymine DNA glycosylase (tdg), thymine DNA glycosylase (Tdg), thymine-DNA glycosylase (Tdg), 5-MCDG, E130317C12Rik, hTDG, JZA-3, Jza1, MGC82456, MGC89441, wu:fb44b11, zgc:110622Protein level used designations for TDG
- G/T mismatch-specific thymine DNA glycosylase
- G/T mismatch DNA glycosylase
- G/t mismatch-specific thymine DNA glycosylase
- thymine-DNA glycosylase
- G/T mismatch-specific thymine DNA glycosylase-like
- g/T mismatch-specific thymine DNA glycosylase-like
- C-JUN leucine zipper interactive protein JZA-3
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