TCIRG1 Products
(T-Cell, Immune Regulator 1, ATPase, H+ Transporting, Lysosomal V0 Subunit A3 (TCIRG1))
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Through alternate splicing, this gene encodes two proteins with similarity to subunits of the vacuolar ATPase (V-ATPase) but the encoded proteins seem to have different functions. V-ATPase is a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, Jul 2008].
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Featured TCIRG1 Categories
TCIRG1 Antibodies
High quality antibodies with extensive validation data.
TCIRG1 ELISA Kits
Reliable ELISA kits for a wide range of species.
TCIRG1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TCIRG1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IHC
Validations
- (6)
Cat. No.
ABIN7270707
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IF, IHC
Validations
- (3)
Cat. No.
ABIN7175220
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, FACS
Validations
- (2)
Cat. No.
ABIN6243315
Quantity
200 μL
Datasheet
Datasheet
Recommended TCIRG1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959842
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN572427
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5659081
Quantity
96 tests
Datasheet
Datasheet
Recommended TCIRG1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322386
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322388
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322384
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our TCIRG1 products
: "A comparison of osteoclast-rich and osteoclast-poor osteopetrosis in adult mice sheds light on the role of the osteoclast in coupling bone resorption and bone formation." in: Calcified tissue international, Vol. 95, Issue 1, pp. 83-93, (2014) (PubMed).: "A specific subtype of osteoclasts secretes factors inducing nodule formation by osteoblasts." in: Bone, Vol. 51, Issue 3, pp. 353-61, (2012) (PubMed).
: "Murine ameloblasts are immunonegative for Tcirg1, the v-H-ATPase subunit essential for the osteoclast plasma proton pump." in: Bone, Vol. 50, Issue 4, pp. 901-8, (2012) (PubMed).
: "Impaired gastric acidification negatively affects calcium homeostasis and bone mass. ..." in: Nature medicine, Vol. 15, Issue 6, pp. 674-81, (2009) (PubMed).
: "Differential localization of vacuolar H+-ATPases containing a1, a2, a3, or a4 (ATP6V0A1-4) subunit isoforms along the nephron." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 20, Issue 1-4, pp. 109-20, (2007) (PubMed).
Synonyms and alternative names related to TCIRG1
T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 (Tcirg1), T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 (Tcirg1), T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3 (TCIRG1), a3, ATP6a3, Atp6i, ATP6N1C, ATP6V0A3, oc, OC-116, OC-116kDa, OC116, OPTB1, Stv1, TIRC7, Vph1Protein level used designations for TCIRG1
- ATPase, H+ transporting, lysosomal V0 protein a
- T cell immune response cDNA7 protein
- T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
- T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a
- V-type proton ATPase 116 kDa subunit a
- V-type proton ATPase 116 kDa subunit a isoform 3
- osteoclastic proton pump
- v-ATPase 116-kDa
- v-H+ATPase subunit a3
- ATPase, H+ transporting, lysosomal I
- T-cell, immune regulator 1
- V-ATPase a3
- osteosclerotic
- ATPase, H+ transporting, 116kD
- OC-116 kDa
- T-cell immune response cDNA 7
- V-ATPase 116-kDa
- osteoclastic proton pump 116 kDa subunit
- specific 116-kDa vacuolar proton pump subunit
- vacuolar proton translocating ATPase 116 kDa subunit A
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