TCF3 Products
(Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3))
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This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1\;19), with PBX1), childhood leukemia (t(19\;19), with TFPT) and acute leukemia (t(12\;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011].
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Featured TCF3 Categories
TCF3 Antibodies
High quality antibodies with extensive validation data.
TCF3 ELISA Kits
Reliable ELISA kits for a wide range of species.
TCF3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TCF3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, FACS, IHC (p)
Validations
- (5)
Cat. No.
ABIN657912
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (3)
Cat. No.
ABIN563112
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (2)
- (2)
Cat. No.
ABIN1724729
Quantity
100 μL
Datasheet
Datasheet
Recommended TCF3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970767
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN5661964
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN5595121
Quantity
96 tests
Datasheet
Datasheet
Recommended TCF3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322367
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7422253
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3133067
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our TCF3 products
: "Sustained endoplasmic reticulum stress inhibits hepatocyte proliferation via downregulation of c-Met expression." in: Molecular and cellular biochemistry, Vol. 389, Issue 1-2, pp. 151-8, (2014) (PubMed).: "T cell factor 4 is a pro-catabolic and apoptotic factor in human articular chondrocytes by potentiating nuclear factor ?B signaling." in: The Journal of biological chemistry, Vol. 288, Issue 24, pp. 17552-8, (2013) (PubMed).
: "Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 29146-57, (2009) (PubMed).
: "Accelerated Notch-dependent degradation of E47 proteins in aged B cell precursors is associated with increased ERK MAPK activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 6, pp. 3521-9, (2007) (PubMed).
: "Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes." in: The Journal of biological chemistry, Vol. 279, Issue 43, pp. 45028-35, (2004) (PubMed).
: "Positive regulation of myogenic bHLH factors and skeletal muscle development by the cell surface receptor CDO." in: Developmental cell, Vol. 7, Issue 6, pp. 843-54, (2004) (PubMed).
: "Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities." in: The EMBO journal, Vol. 22, Issue 21, pp. 5780-92, (2003) (PubMed).
: "Inhibition of Tcf3 binding by I-mfa domain proteins." in: Molecular and cellular biology, Vol. 21, Issue 5, pp. 1866-73, (2001) (PubMed).
: "The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function." in: The Journal of biological chemistry, Vol. 275, Issue 43, pp. 33567-73, (2000) (PubMed).
: "Both E12 and E47 allow commitment to the B cell lineage." in: Immunity, Vol. 6, Issue 2, pp. 145-54, (1997) (PubMed).
Synonyms and alternative names related to TCF3
transcription factor 3 (TCF3), transcription factor 3b (tcf3b), transcription factor 3 (Tcf3), transcription factor 3 L homeolog (tcf3.L), transcription factor E2a (tcfe2a), A1, AA408400, ALF2, AW209082, bHLHb21, bhlhb21, E2A, e2a, E12, E12/E47, E47, G12, ITF1, itf1, ME2, Pan1, Pan2, TCF-3, tcf3a, TCF7L1, Tcfe2a, tcfe2a, VDIR, vdir, XE3, xtcf-3, xtcf3, zgc:113045Protein level used designations for TCF3
- VDR interacting repressor
- class B basic helix-loop-helix protein 21
- helix-loop-helix protein HE47
- immunoglobulin transcription factor 1
- kappa-E2-binding factor
- negative vitamin D response element-binding protein
- transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
- transcription factor E2-alpha
- transcription factor ITF-1
- vitamin D receptor-interacting repressor
- transcription factor 3
- TCF-3
- immunoglobulin enhancer-binding factor E12/E47
- transcription factor A1
- transcription factor E2a
- pancreas specific transcription factor 1c
- transcription regulator Pan
- transcription factor XE12/XE47
- class A basic helix-loop-helix transcription factor G12
- helix-loop-helix protein E12
- helix-loop-helix protein E47
- transcription factor 7-like 1 (T-cell specific, HMG-box)
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