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TBXAS1 Products

(thromboxane A Synthase 1 (Platelet) (TBXAS1))

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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

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Featured TBXAS1 Categories

TBXAS1 Antibodies

High quality antibodies with extensive validation data.

TBXAS1 ELISA Kits

Reliable ELISA kits for a wide range of species.

TBXAS1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TBXAS1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Rat
Application WB, IHC, IF, IHC (p), FACS
Validations
  • (8)
Cat. No. ABIN1501382
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, IHC (p), FACS
Validations
  • (6)
Cat. No. ABIN1501383
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC (p)
Validations
  • (3)
Cat. No. ABIN752623
Quantity 100 μL
Datasheet Datasheet

Recommended TBXAS1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970643
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970644
Quantity 96 tests
Datasheet Datasheet
Reactivity Guinea Pig
Analytical Method Quantitative
Validations
Cat. No. ABIN777809
Quantity 96 tests
Datasheet Datasheet

Recommended TBXAS1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1322310
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7417933
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3097044
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our TBXAS1 products

Valkonen, Holopainen, Colas, Impola, Dalli, Käkelä, Siljander, Laitinen: "Lipid mediators in platelet concentrate and extracellular vesicles: Molecular mechanisms from membrane glycerophospholipids to bioactive molecules." in: Biochimica et biophysica acta. Molecular and cell biology of lipids, Vol. 1864, Issue 8, pp. 1168-1182, (2019) (PubMed).

Minami, Takigawa, Kato, Kudo, Isozaki, Hashida, Harada, Ochi, Fujii, Kubo, Ohashi, Sato, Tanaka, Hotta, Tabata, Toyooka, Tanimoto, Kiura: "Downregulation of TBXAS1 in an iron-induced malignant mesothelioma model." in: Cancer science, Vol. 106, Issue 10, pp. 1296-302, (2015) (PubMed).

Meling, Zelasko, Kambalyal, Roy, Das: "Functional role of the conserved i-helix residue I346 in CYP5A1-Nanodiscs." in: Biophysical chemistry, Vol. 200-201, pp. 34-40, (2015) (PubMed).

Huang, Chu, Jiang, Chen, Zhang, Zeng: "Glycyrrhizin suppresses lung adenocarcinoma cell growth through inhibition of thromboxane synthase." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 33, Issue 2, pp. 375-88, (2014) (PubMed).

Das, Varma, Mularczyk, Meling: "Functional investigations of thromboxane synthase (CYP5A1) in lipid bilayers of nanodiscs." in: Chembiochem : a European journal of chemical biology, Vol. 15, Issue 6, pp. 892-9, (2014) (PubMed).

Huang, Chu, Huang, Chen, Jiang, Zhang, Zeng: "18β-Glycyrrhetinic acid suppresses cell proliferation through inhibiting thromboxane synthase in non-small cell lung cancer." in: PLoS ONE, Vol. 9, Issue 4, pp. e93690, (2014) (PubMed).

Synonyms and alternative names related to TBXAS1

thromboxane-A synthase (PTRG_00454), thromboxane-A synthase (PTRG_06796), Thromboxane-A synthase (thas), thromboxane A synthase 1 (TBXAS1), thromboxane A synthase 1 (platelet) (tbxas1), thromboxane A synthase 1, platelet (Tbxas1), thromboxane A synthase 1 (Tbxas1), BDPLT14, CYP5, CYP5A1, GHOSAL, TBXAS1, thas, THAS, TS, TXAS, TXS, wu:fk19d08, zgc:136708

Protein level used designations for TBXAS1

  • thromboxane-A synthase
  • Thromboxane-A synthase
  • thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)
  • thromboxane A synthase 1 (platelet)
  • thromboxane-A synthase-like
  • TXA synthase
  • cytochrome P450 5A1
  • cytochrome P450, family 5, subfamily A, polypeptide 1
  • platelet, cytochrome P450, subfamily V
  • TXS
  • thromboxane A synthase 1, platelet
  • ThromboxA ane synthase 1
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