TBP Products
(TATA Box Binding Protein (TBP))
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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010].
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Featured TBP Categories
TBP Antibodies
High quality antibodies with extensive validation data.
TBP ELISA Kits
Reliable ELISA kits for a wide range of species.
TBP Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TBP Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, ICC, FACS
Validations
- (8)
Cat. No.
ABIN7193395
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF, FACS
Validations
- (6)
Cat. No.
ABIN3029099
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human, Monkey, Mouse, Rat
Application
WB, ELISA, IHC (p)
Validations
- (8)
Cat. No.
ABIN3029100
Quantity
0.4 mL
Datasheet
Datasheet
Recommended TBP ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN511633
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Chicken
Analytical Method
Quantitative
Validations
Cat. No.
ABIN1059007
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Monkey
Analytical Method
Quantitative
Validations
Cat. No.
ABIN1059008
Quantity
96 tests
Datasheet
Datasheet
Recommended TBP Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322267
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7420309
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7413751
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our TBP products
: "Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 303, Issue 6, pp. L519-27, (2012) (PubMed).: "Identification of novel functional TBP-binding sites and general factor repertoires." in: The EMBO journal, Vol. 26, Issue 4, pp. 944-54, (2007) (PubMed).
: "Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction." in: PLoS biology, Vol. 4, Issue 3, pp. e67, (2006) (PubMed).
: "HIV-1 Tat stimulates transcription complex assembly through recruitment of TBP in the absence of TAFs." in: PLoS biology, Vol. 3, Issue 2, pp. e44, (2005) (PubMed).
: "TBP, a polyglutamine tract containing protein, accumulates in Alzheimer's disease." in: Brain research. Molecular brain research, Vol. 125, Issue 1-2, pp. 120-8, (2004) (PubMed).
: "Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids." in: Development (Cambridge, England), Vol. 129, Issue 4, pp. 945-55, (2002) (PubMed).
: "Distinct TFIID complexes mediate the effect of different transcriptional activators." in: The EMBO journal, Vol. 12, Issue 2, pp. 489-99, (1993) (PubMed).
: "Highly conserved core domain and unique N terminus with presumptive regulatory motifs in a human TATA factor (TFIID)." in: Nature, Vol. 346, Issue 6282, pp. 387-90, (1990) (PubMed).
: "Functional domains and upstream activation properties of cloned human TATA binding protein." in: Science (New York, N.Y.), Vol. 248, Issue 4963, pp. 1625-30, (1990) (PubMed).
: "Cloning of a transcriptionally active human TATA binding factor." in: Science (New York, N.Y.), Vol. 248, Issue 4963, pp. 1646-50, (1990) (PubMed).
Synonyms and alternative names related to TBP
TATA-box binding protein (TBP), TATA box binding protein (Tbp), TATA box binding protein (tbp), TATA box binding protein (TBP), TATA-box binding protein (tbp), TATA binding protein (Tbp), TATA-box binding protein L homeolog (tbp.L), TATA-box binding protein (Tbp), TATA-box-binding protein (Tbp), TATA-box binding protein S homeolog (tbp.S), CG9874, Dmel\\CG9874, dTBP, dTbp, dtbp, dTFIID, fd20h06, GTF2D, Gtf2d, gtf2d, GTF2D1, gtf2d1, HDL4, RBP, SCA17, sca17, si:zc101n13.2, TBP, tbp, tbp-a, tbp-b, TBP1, TBP38, TFIID, TfIID, tfiid, TFIIDtau, tfiidtau, wu:fd20h06, xtbp, zgc:66213Protein level used designations for TBP
- TATA sequence-binding protein
- TATA-box binding protein N-terminal domain
- TATA-box factor
- TATA-box-binding protein
- transcription initiation factor TFIID TBP subunit
- TATA-binding factor
- TATA-binding protein
- TFIID core protein
- zTBP
- zfTBF
- TA-TA binding protein 1
- TATA binding protein
- TATA box binding protein
- 42kDa polypeptide
- CG9874-PA
- TATA box-binding protein
- TATA-box binding protein
- Tbp-PA
- transcription factor
- Transcription initiation factor TFIID TBP subunit
- TATA-box binding protein S homeolog
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