T-Box 5 Products
(T-Box 5 (TBX5))
Categories
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
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Featured T-Box 5 Categories
T-Box 5 Antibodies
High quality antibodies with extensive validation data.
T-Box 5 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended T-Box 5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, RNAi
Validations
- (3)
- (3)
Cat. No.
ABIN563098
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7239203
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Bat, Chicken, Cow, Dog, Goat, Guinea Pig, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat, Sheep, Xenopus laevis, Zebrafish (Danio rerio)
Application
WB, IHC, IHC (p)
Validations
- (3)
Cat. No.
ABIN6741551
Quantity
100 μL
Datasheet
Datasheet
Recommended T-Box 5 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6221767
Quantity
96 tests
Datasheet
Datasheet
Recommended T-Box 5 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322304
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322302
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7423756
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our T-Box 5 products
: "A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases." in: Circulation research, Vol. 120, Issue 10, pp. 1561-1571, (2017) (PubMed).: "TBX5 mutations contribute to early-onset atrial fibrillation in Chinese and Caucasians." in: Cardiovascular research, Vol. 109, Issue 3, pp. 442-50, (2016) (PubMed).
: "Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo." in: PLoS ONE, Vol. 10, Issue 10, pp. e0140831, (2015) (PubMed).
: "Kctd10 regulates heart morphogenesis by repressing the transcriptional activity of Tbx5a in zebrafish." in: Nature communications, Vol. 5, pp. 3153, (2014) (PubMed).
: "Holt-Oram syndrome with intermediate atrioventricular canal defect, and aortic coarctation: functional characterization of a de novo TBX5 mutation." in: American journal of medical genetics. Part A, Vol. 164A, Issue 6, pp. 1419-24, (2014) (PubMed).
: "Directing cardiomyogenic differentiation of human pluripotent stem cells by plasmid-based transient overexpression of cardiac transcription factors." in: Stem cells and development, Vol. 22, Issue 7, pp. 1112-25, (2013) (PubMed).
: "Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling." in: Aquatic toxicology (Amsterdam, Netherlands), Vol. 142-143, pp. 26-32, (2013) (PubMed).
: "Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions." in: Nature protocols, Vol. 8, Issue 1, pp. 162-75, (2012) (PubMed).
: "Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos." in: Journal of biomedical science, Vol. 18, pp. 73, (2011) (PubMed).
: "Physical interaction between TBX5 and MEF2C is required for early heart development." in: Molecular and cellular biology, Vol. 29, Issue 8, pp. 2205-18, (2009) (PubMed).
Synonyms and alternative names related to T-Box 5
T-box 5 (TBX5), T-box 5 (tbx5), T-box 5 L homeolog (tbx5.L), T-box 5 (Tbx5), T-box 5a (tbx5a), HOS, tbx-5, TBX5, tbx5, tbx5.1, xtbx-5, xtbx5, zf-tbx5, zTbx5Protein level used designations for T-Box 5
- T-box 5
- T-box protein 5
- T-box transcription factor 5
- T-box transcription factor TBX5
- T-box transcription factor TBX5-like
- t-box transcription factor TBX5-like
- T-box gene 5
- T-box gene 5.1
- T-box transcription factor TBX5-A
- etID310031.5
- heartstrings
- hst
- zftbx5a
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