TAF4 Products
(TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4))
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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq, Jul 2008].
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Featured TAF4 Categories
TAF4 Antibodies
High quality antibodies with extensive validation data.
TAF4 ELISA Kits
Reliable ELISA kits for a wide range of species.
TAF4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TAF4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF, ICC
Validations
- (3)
Cat. No.
ABIN6265437
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
Cat. No.
ABIN6244013
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
IF, IHC
Validations
- (2)
Cat. No.
ABIN7075827
Quantity
100 μL
Datasheet
Datasheet
Recommended TAF4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN5648297
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN511631
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Chicken
Analytical Method
Quantitative
Validations
Cat. No.
ABIN1059016
Quantity
96 tests
Datasheet
Datasheet
Recommended TAF4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322093
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3095791
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Candida albicans
Source
Yeast
Validations
Cat. No.
ABIN1631845
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our TAF4 products
: "Redundant role of tissue-selective TAF(II)105 in B lymphocytes." in: Molecular and cellular biology, Vol. 22, Issue 18, pp. 6564-72, (2002) (PubMed).: "Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription. ..." in: Nature genetics, Vol. 26, Issue 1, pp. 29-36, (2000) (PubMed).
: "Distinct subdomains of human TAFII130 are required for interactions with glutamine-rich transcriptional activators." in: Molecular and cellular biology, Vol. 18, Issue 10, pp. 5734-43, (1998) (PubMed).
: "Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells." in: Genes & development, Vol. 11, Issue 11, pp. 1381-95, (1997) (PubMed).
Synonyms and alternative names related to TAF4
TBP-associated factor 4 (Taf4), Taf4p (TAF4), TATA-box binding protein associated factor 4 (TAF4), TATA-box binding protein associated factor 4 L homeolog (taf4.L), CG5444, d110, Dmel\\CG5444, dmTAF4, dTAF4, dTAFII110, dTAF[[II]]110, l(3)72Dj, p110, SR3-3, SY3-2 TAF110, TAF, TAF2C, TAF2C1, TAF4, TAF4A, TAF110, Taf110, taf110, TAFII110, TAFII130, TAFII135, TAF[II]110, TAF[[II]], TAF[[II]]110, Taf[[II]]110, TFIID, TFIID 110Protein level used designations for TAF4
- CG5444-PA
- CG5444-PB
- CG5444-PC
- CG5444-PD
- CG5444-PE
- CG5444-PF
- CG5444-PG
- CG5444-PH
- TATA-associated factor 110
- TBP associated factor 110
- TBP-associated factor
- TBP-associated factor 110
- TBP-associated factor 110kD
- Taf4-PA
- Taf4-PB
- Taf4-PC
- Taf4-PD
- Taf4-PE
- Taf4-PF
- Taf4-PG
- Taf4-PH
- lethal(3)72Dj
- hypothetical protein
- RNA polymerase II TBP-associated factor subunit C
- TAF(II)130
- TAF(II)135
- TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135 kD
- TAFII-130
- TAFII-135
- TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kD
- TBP-associated factor 4
- transcription initiation factor TFIID 130 kDa subunit
- transcription initiation factor TFIID 135 kD subunit
- transcription initiation factor TFIID 135 kDa subunit
- transcription initiation factor TFIID subunit 4
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