SUV39H2 Products
(Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))
Categories
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes (By similarity).
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Featured SUV39H2 Categories
SUV39H2 Antibodies
High quality antibodies with extensive validation data.
SUV39H2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SUV39H2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (3)
- (3)
Cat. No.
ABIN388081
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC, IF
Validations
- (4)
Cat. No.
ABIN7075771
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, IHC
Validations
- (5)
Cat. No.
ABIN3029054
Quantity
0.4 mL
Datasheet
Datasheet
Recommended SUV39H2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6232503
Quantity
96 tests
Datasheet
Datasheet
Recommended SUV39H2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321939
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3095760
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3137192
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SUV39H2 products
: "IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP." in: eLife, Vol. 8, (2019) (PubMed).: "Alternative splicing regulates the expression of G9A and SUV39H2 methyltransferases, and dramatically changes SUV39H2 functions." in: Nucleic acids research, Vol. 43, Issue 3, pp. 1869-82, (2015) (PubMed).
: "Histone-modifying genes as biomarkers in hepatocellular carcinoma." in: International journal of clinical and experimental pathology, Vol. 7, Issue 5, pp. 2496-507, (2015) (PubMed).
: "High expressions of histone methylation- and phosphorylation-related proteins are associated with prognosis of oral squamous cell carcinoma in male population of Taiwan." in: Medical oncology (Northwood, London, England), Vol. 30, Issue 2, pp. 513, (2013) (PubMed).
: "Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia." in: Molecular and cellular biology, Vol. 31, Issue 10, pp. 1949-58, (2011) (PubMed).
: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
: "Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability." in: Cell, Vol. 107, Issue 3, pp. 323-37, (2001) (PubMed).
: "Regulation of chromatin structure by site-specific histone H3 methyltransferases." in: Nature, Vol. 406, Issue 6796, pp. 593-9, (2000) (PubMed).
: "Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression." in: Molecular and cellular biology, Vol. 20, Issue 24, pp. 9423-33, (2000) (PubMed).
Synonyms and alternative names related to SUV39H2
suppressor of variegation 3-9 homolog 2 (SUV39H2), suppressor of variegation 3-9 homolog 2 (Drosophila) (Suv39h2), suppressor of variegation 3-9 homolog 2 (Suv39h2), suppressor of variegation 3-9 homolog 2 (suv39h2), suppressor of variegation 3-9 homolog 2 L homeolog (suv39h2.L), 4930507K23Rik, AA536750, D030054H19Rik, D2Ertd544e, KMT1B, kmt1b, SUV39H2Protein level used designations for SUV39H2
- H3-K9-HMTase 2
- histone H3-K9 methyltransferase 2
- histone-lysine N-methyltransferase SUV39H2
- lysine N-methyltransferase 1B
- su(var)3-9 homolog 2
- Suv39h histone methyltransferase
- suppressor of variegation 3-9 homolog 2 (Drosophila)
- histone-lysine N-methyltransferase SUV39H2-like
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