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SUPV3L1 Products

(Suppressor of Var1, 3-Like 1 (SUPV3L1))

Categories

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria\; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA (By similarity).

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Featured SUPV3L1 Categories

SUPV3L1 Antibodies

High quality antibodies with extensive validation data.

SUPV3L1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SUPV3L1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, FACS, IHC (p)
Validations
  • (5)
  • (4)
Cat. No. ABIN1881857
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (5)
Cat. No. ABIN520625
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7145007
Quantity 100 μL
Datasheet Datasheet

Recommended SUPV3L1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6233067
Quantity 96 tests
Datasheet Datasheet

Recommended SUPV3L1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1321919
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2733011
Quantity 20 μg
Datasheet Datasheet
Reactivity Rat
Source Yeast
Validations
Cat. No. ABIN1631978
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our SUPV3L1 products

Szczesny, Borowski, Brzezniak, Dmochowska, Gewartowski, Bartnik, Stepien: "Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance." in: Nucleic acids research, Vol. 38, Issue 1, pp. 279-98, (2010) (PubMed).

Wang, Shu, Lieser, Chen, Lee: "Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality." in: The Journal of biological chemistry, Vol. 284, Issue 31, pp. 20812-21, (2009) (PubMed).

Khidr, Wu, Davila, Procaccio, Wallace, Lee: "Role of SUV3 helicase in maintaining mitochondrial homeostasis in human cells." in: The Journal of biological chemistry, Vol. 283, Issue 40, pp. 27064-73, (2008) (PubMed).

Bogenhagen, Rousseau, Burke: "The layered structure of human mitochondrial DNA nucleoids." in: The Journal of biological chemistry, Vol. 283, Issue 6, pp. 3665-75, (2008) (PubMed).

Pereira, Mason, Szczesny, Maddukuri, Dziwura, Jedrzejczak, Paul, Wojcik, Dybczynska, Tudek, Bartnik, Klysik, Bohr, Stepien: "Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality." in: Mechanisms of ageing and development, Vol. 128, Issue 11-12, pp. 609-17, (2007) (PubMed).

Synonyms and alternative names related to SUPV3L1

Suv3 like RNA helicase (SUPV3L1), suppressor of var1, 3-like 1 (S. cerevisiae) (Supv3l1), Suv3 like RNA helicase (Supv3l1), SUV3-like helicase (supv3l1), 6330443E10Rik, SUV3, wu:fc19b02, wu:fe37e06

Protein level used designations for SUPV3L1

  • ATP-dependent RNA helicase SUPV3L1, mitochondrial
  • SUV3-like protein 1
  • suppressor of var1 3-like protein 1
  • suppressor of var1, 3-like 1(SUV3)
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