SUPT5H Products
(Transcription Elongation Factor SPT5 (SUPT5H))
Categories
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV- 1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
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Featured SUPT5H Categories
SUPT5H Antibodies
High quality antibodies with extensive validation data.
SUPT5H ELISA Kits
Reliable ELISA kits for a wide range of species.
SUPT5H Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SUPT5H Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (4)
Cat. No.
ABIN520620
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application
WB, IHC, IHC (p)
Validations
- (3)
Cat. No.
ABIN6735860
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Rabbit, Zebrafish (Danio rerio)
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN2777903
Quantity
100 μL
Datasheet
Datasheet
Recommended SUPT5H ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1162213
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1162214
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Chicken
Analytical Method
Validations
Cat. No.
ABIN1162212
Quantity
96 tests
Datasheet
Datasheet
Recommended SUPT5H Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321917
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3131899
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3095662
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SUPT5H products
: "Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism." in: eLife, Vol. 4, pp. e06535, (2015) (PubMed).: "Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway." in: Nature communications, Vol. 3, pp. 976, (2012) (PubMed).
: "A role for the RNA pol II-associated PAF complex in AID-induced immune diversification." in: The Journal of experimental medicine, Vol. 209, Issue 11, pp. 2099-111, (2012) (PubMed).
: "Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice." in: Cell, Vol. 128, Issue 1, pp. 71-83, (2007) (PubMed).
: "Differential regulation of NF-kappaB by elongation factors is determined by core promoter type." in: Molecular and cellular biology, Vol. 27, Issue 14, pp. 5246-59, (2007) (PubMed).
Synonyms and alternative names related to SUPT5H
SPT5 homolog, DSIF elongation factor subunit (SUPT5H), transcription elongation factor SPT5 (LOC413814), Transcription elongation factor Spt5 (AT2G34210), transcription elongation factor Spt5 (spt5), transcription elongation factor spt5 (MGYG_08422), transcription elongation factor spt5 (TERG_05483), hypothetical protein (PGTG_18458), SPT5 homolog, DSIF elongation factor subunit (supt5h), SPT5 homolog, DSIF elongation factor subunit (Supt5h), SPT5 homolog, DSIF elongation factor subunit S homeolog (supt5h.S), CG7626 gene product from transcript CG7626-RA (Spt5), Transcription elongation factor SPT5 (spt-5), transcription elongation factor (SPT5), CaO19.1453, CG7626, dDSIF, Dmel\\CG7626, DSIF, Dspt5, dSpt5, etID10129.15, etID37101.15, F13P17.5, F13P17_5, fb37g01, fb95e05, fog, foggy, SPT5, Spt5, spt5, SPT5H, spt5h, Tat-CT1, tat-ct1, wu:fb37g01, wu:fb95e05, wu:fc10f02Protein level used designations for SUPT5H
- DRB sensitivity-inducing factor 160 kDa subunit
- DRB sensitivity-inducing factor large subunit
- DSIF large subunit
- DSIF p160
- Tat-cotransactivator 1 protein
- hSPT5
- transcription elongation factor SPT5
- transcription elongation factor Spt5
- transcription elongation factor spt5
- protein foggy
- transcription elongation regulator foggy
- CG7626-PA
- Spt5-PA
- Chromatin elongation factor SPT5
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