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SULF2 Products

(Sulfatase 2 (SULF2))
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008].

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Featured SULF2 Categories

SULF2 Antibodies

High quality antibodies with extensive validation data.

SULF2 ELISA Kits

Reliable ELISA kits for a wide range of species.

SULF2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SULF2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7441439
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7152346
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (3)
Cat. No. ABIN7436405
Quantity 100 μL
Datasheet Datasheet

Recommended SULF2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
  • (1)
Cat. No. ABIN6959739
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959740
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN454343
Quantity 96 tests
Datasheet Datasheet

Recommended SULF2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1321862
Quantity 2 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1321860
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7408879
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our SULF2 products

Alyoussef, Al-Gayyar: "Cytotoxic and partial hepatoprotective activity of sodium ascorbate against hepatocellular carcinoma through inhibition of sulfatase-2 in vivo and in vitro." in: Biomedicine & pharmacotherapy, Vol. 103, pp. 362-372, (2018) (PubMed).

Yue: "Epithelial Deletion of Sulf2 Exacerbates Bleomycin-Induced Lung Injury, Inflammation, and Mortality." in: American journal of respiratory cell and molecular biology, Vol. 57, Issue 5, pp. 560-569, (2017) (PubMed).

Zhu, He, Zhou, Nie, Gu: "Sulfatase 2 promotes breast cancer progression through regulating some tumor-related factors." in: Oncology reports, Vol. 35, Issue 3, pp. 1318-28, (2016) (PubMed).

Zaghloul, El-Shishtawy, El Galil, Ebrahim, Metwaly, Al-Gayyar: "Evaluation of antiglypican-3 therapy as a promising target for amelioration of hepatic tissue damage in hepatocellular carcinoma." in: European journal of pharmacology, Vol. 746, pp. 353-62, (2014) (PubMed).

Solari, Borriello, Turcatel, Shimada, Sposto, Fernandez, Asgharzadeh, Yates, Turnbull, DeClerck: "MYCN-dependent expression of sulfatase-2 regulates neuroblastoma cell survival." in: Cancer research, Vol. 74, Issue 21, pp. 5999-6009, (2014) (PubMed).

Yue, Lu, Auduong, Sides, Lasky: "Overexpression of Sulf2 in idiopathic pulmonary fibrosis." in: Glycobiology, Vol. 23, Issue 6, pp. 709-19, (2013) (PubMed).

Lui, van Zante, Rosen, Jablons, Lemjabbar-Alaoui: "SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study." in: BMJ open, Vol. 2, Issue 6, (2012) (PubMed).

Lemjabbar-Alaoui, van Zante, Singer, Xue, Wang, Tsay, He, Jablons, Rosen: "Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis." in: Oncogene, Vol. 29, Issue 5, pp. 635-46, (2010) (PubMed).

Uchimura, Morimoto-Tomita, Bistrup, Li, Lyon, Gallagher, Werb, Rosen: "HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1." in: BMC biochemistry, Vol. 7, pp. 2, (2006) (PubMed).

Ai, Do, Kusche-Gullberg, Lindahl, Lu, Emerson: "Substrate specificity and domain functions of extracellular heparan sulfate 6-O-endosulfatases, QSulf1 and QSulf2." in: The Journal of biological chemistry, Vol. 281, Issue 8, pp. 4969-76, (2006) (PubMed).

Synonyms and alternative names related to SULF2

sulfatase 2a (sulf2a), sulfatase 2 (SULF2), extracellular sulfatase Sulf-2 (LOC100540921), sulfatase 2 (sulf2), sulfatase 2b (sulf2b), sulfatase 2 S homeolog (sulf2.S), sulfatase 2 (Sulf2), 2010004N24Rik, AU020235, HSULF-2, mKIAA1247, MSulf-2, si:dkeyp-84g9.1, Sulf1, SULF2, wu:fb48e04, xtsulf2, zgc:55612

Protein level used designations for SULF2

  • sulfatase 2
  • extracellular sulfatase Sulf-2-like
  • extracellular sulfatase Sulf-2
  • sulf2a
  • sulfatase FP2a
  • sulfatase FP2b
  • sulfatase FP2
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