STRADB Products
(STE20-Related Kinase Adaptor beta (STRADB))
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This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
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Featured STRADB Categories
STRADB Antibodies
High quality antibodies with extensive validation data.
STRADB Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended STRADB Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (5)
Cat. No.
ABIN527535
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
Cat. No.
ABIN184938
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7170733
Quantity
100 μg
Datasheet
Datasheet
Recommended STRADB ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6212609
Quantity
96 tests
Datasheet
Datasheet
Recommended STRADB Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (2)
Cat. No.
ABIN1321745
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321747
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321749
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our STRADB products
: "Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily." in: Advances in protein chemistry, Vol. 68, pp. 225-79, (2004) (PubMed).: "Analogies between Drosophila and mammalian TRAF pathways." in: Progress in molecular and subcellular biology, Vol. 34, pp. 47-72, (2004) (PubMed).
: "The Toll-IL-1 receptor adaptor family grows to five members." in: Trends in immunology, Vol. 24, Issue 6, pp. 286-90, (2003) (PubMed).
: "TRAF6 is a critical factor for dendritic cell maturation and development." in: Immunity, Vol. 19, Issue 3, pp. 353-63, (2003) (PubMed).
: "Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase." in: The Journal of biological chemistry, Vol. 278, Issue 15, pp. 13520-30, (2003) (PubMed).
: "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis." in: The Journal of biological chemistry, Vol. 277, Issue 34, pp. 30454-62, (2002) (PubMed).
: "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2." in: Genomics, Vol. 71, Issue 2, pp. 200-13, (2001) (PubMed).
Synonyms and alternative names related to STRADB
STE20-related kinase adaptor beta (Stradb), STE20-related kinase adaptor beta (STRADB), STE20-related kinase adaptor beta L homeolog (stradb.L), AA792893, Als2cr2, als2cr2, ALS2CR2, B830008M19, CALS-21, D1Ucla2, ILPIP, ILPIPA, MGC82468, Papk, PAPK, PRO1038, RGD1559449, STRADB, SyradbProtein level used designations for STRADB
- polyploidy associated protein kinase PAPK-A
- amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2
- STE20-related kinase adaptor beta
- STE20-related kinase adapter protein beta
- juvenile amyotrophic lateral sclerosis 2 candidate 2
- STE20-related kinase adapter protein beta-like
- ILP-interacting protein homolog
- STRAD beta
- amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog
- polyploidy associated protein kinase
- polyploidy-associated protein kinase
- pseudokinase ALS2CR2
- ILP-interacting protein ILPIPA
- amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein
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