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STIM1 Products

(Stromal Interaction Molecule 1 (STIM1))

Categories

This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.[provided by RefSeq, Jan 2009].

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Featured STIM1 Categories

STIM1 Antibodies

High quality antibodies with extensive validation data.

STIM1 ELISA Kits

Reliable ELISA kits for a wide range of species.

STIM1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended STIM1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), IF
Validations
  • (20)
  • (5)
Cat. No. ABIN563045
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (5)
Cat. No. ABIN7444409
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IP, IHC (p), ICC
Validations
  • (2)
  • (3)
Cat. No. ABIN192394
Quantity 0.1 mg
Datasheet Datasheet

Recommended STIM1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6730286
Quantity 96 tests
Datasheet Datasheet

Recommended STIM1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1321631
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN666653
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7418308
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our STIM1 products

Zhou, Gu, Li, Li, Zhu, Gao, Zang, Wang, Shan, Yang: "Suppression of STIM1 inhibits the migration and invasion of human prostate cancer cells and is associated with PI3K/Akt signaling inactivation." in: Oncology reports, Vol. 38, Issue 5, pp. 2629-2636, (2018) (PubMed).

Wu, Hsu, Wang, Liang, Tsai, Yen, Li, Chiu, Chang, Huang, Lin, Yoshioka: "A Novel Strategy for TNF-Alpha Production by 2-APB Induced Downregulated SOCE and Upregulated HSP70 in O. tsutsugamushi-Infected Human Macrophages." in: PLoS ONE, Vol. 11, Issue 7, pp. e0159299, (2017) (PubMed).

Chen, Zhang, Wu, Shi, Yan, Mei, Tolleson, Guo: "Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 146, Issue 1, pp. 116-26, (2015) (PubMed).

Hong, Chang, Wang, Yu, Lee: "IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes: A plausible mechanism of IL-9R in atopic dermatitis." in: Journal of dermatological science, Vol. 78, Issue 3, pp. 206-14, (2015) (PubMed).

Wang, Choi, Richardson, Reid, Seymen, Yildirim, Tuna, Gençay, Simmer, Hu: "STIM1 and SLC24A4 Are Critical for Enamel Maturation." in: Journal of dental research, Vol. 93, Issue 7 Suppl, pp. 94S-100S, (2015) (PubMed).

Shalygin, Skopin, Kalinina, Zimina, Glushankova, Mozhayeva, Kaznacheyeva: "STIM1 and STIM2 proteins differently regulate endogenous store-operated channels in HEK293 cells." in: The Journal of biological chemistry, Vol. 290, Issue 8, pp. 4717-27, (2015) (PubMed).

Sogkas, Stegner, Syed, Vögtle, Rau, Gewecke, Schmidt, Nieswandt, Gessner: "Cooperative and alternate functions for STIM1 and STIM2 in macrophage activation and in the context of inflammation." in: Immunity, inflammation and disease, Vol. 3, Issue 3, pp. 154-70, (2015) (PubMed).

Tirado-Lee, Yamashita, Prakriya: "Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding." in: PLoS ONE, Vol. 10, Issue 6, pp. e0128622, (2015) (PubMed).

Ma, Wei, He, Liu, Wu, Zhang, Jing, Liang, Senes, Tan, Li, Sun, Bi, Zhong, Si, Shen, Li, Lee, Zhou, Wang, Wang, Zhou: "Inside-out Ca(2+) signalling prompted by STIM1 conformational switch." in: Nature communications, Vol. 6, pp. 7826, (2015) (PubMed).

Samanta, Kar, Mirams, Parekh: "Ca(2+) Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca(2+)-Dependent Nuclear Gene Expression." in: Cell reports, Vol. 12, Issue 2, pp. 203-16, (2015) (PubMed).

Synonyms and alternative names related to STIM1

stromal interaction molecule 1 (STIM1), stromal interaction molecule 1 (stim1), stromal interaction molecule 1a (stim1a), stromal interaction molecule 1 L homeolog (stim1.L), stromal interaction molecule 1b (stim1b), stromal interaction molecule 1 (Stim1), D11S4896E, GOK, MGC76045, MGC154748, si:ch211-112l17.2, si:dkey-24p1.5, SIM, stim1, STIM1, Stim1, TAM

Protein level used designations for STIM1

  • stromal interaction molecule 1
  • stromal interaction molecule 1b
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