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Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Products

(Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2))
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008].

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Featured Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Categories

Recommended Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Antibodies

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Recommended Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Proteins

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Latest Publications for our Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) products

Ishikawa, Yoshitomi, Covey, Zorumski, Izumi: "TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model." in: Neuropharmacology, Vol. 111, pp. 142-159, (2016) (PubMed).

Tanaka, Miki, Hashimoto, Takagi, Doe, Li, Yaegashi, Suzuki, Ito: "The role of 5α-reductase type 1 associated with intratumoral dihydrotestosterone concentrations in human endometrial carcinoma." in: Molecular and cellular endocrinology, Vol. 401, pp. 56-64, (2015) (PubMed).

Chávez, Ramos, García-Becerra, Vilchis: "Hamster SRD5A3 lacks steroid 5α-reductase activity in vitro." in: Steroids, Vol. 94, pp. 41-50, (2015) (PubMed).

Bertin, Dury, Ouellet, Pelletier, Labrie: "Localization of the androgen-synthesizing enzymes, androgen receptor, and sex steroids in the vagina: possible implications for the treatment of postmenopausal sexual dysfunction." in: The journal of sexual medicine, Vol. 11, Issue 8, pp. 1949-61, (2014) (PubMed).

Sato, Iemitsu, Matsutani, Kurihara, Hamaoka, Fujita: "Resistance training restores muscle sex steroid hormone steroidogenesis in older men." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 4, pp. 1891-7, (2014) (PubMed).

Jang, Bae, Yuk, Han, Ha, Hwang, Yoon, Kim, Han: "Seoritae extract reduces prostate weight and suppresses prostate cell proliferation in a rat model of benign prostate hyperplasia." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 475876, (2014) (PubMed).

Chávez, Ramos, Gómez, Vilchis: "46,XY disorder of sexual development resulting from a novel monoallelic mutation (p.Ser31Phe) in the steroid 5α-reductase type-2 (SRD5A2) gene." in: Molecular genetics & genomic medicine, Vol. 2, Issue 4, pp. 292-6, (2014) (PubMed).

Park, Aizawa, Iemitsu, Sato, Akimoto, Agata, Maeda, Ezawa, Omi: "DHEA administration activates local bioactive androgen metabolism in cancellous site of tibia of ovariectomized rats." in: Calcified tissue international, Vol. 89, Issue 2, pp. 105-10, (2011) (PubMed).

Vilchis, Ramos, Méndez, Benavides, Canto, Chávez et al.: "Molecular analysis of the SRD5A2 in 46,XY subjects with incomplete virilization: the P212R substitution of the steroid 5alpha-reductase 2 may constitute an ancestral founder mutation in Mexican ..." in: Journal of andrology, Vol. 31, Issue 4, pp. 358-64, (2010) (PubMed).

Torkko, van Bokhoven, Mai, Beuten, Balic, Byers, Hokanson, Norris, Barón, Lucia, Thompson, Leach: "VDR and SRD5A2 polymorphisms combine to increase risk for prostate cancer in both non-Hispanic White and Hispanic White men." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 10, pp. 3223-9, (2008) (PubMed).

Synonyms and alternative names related to Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2)

steroid 5 alpha-reductase 2 (SRD5A2), steroid 5 alpha-reductase 2 (Srd5a2), steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (srd5a2), 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (LOC100125532), steroid-5-alpha-reductase, alpha polypeptide 2a (srd5a2a), steroid-5-alpha-reductase, alpha polypeptide 2b (srd5a2b), 5ART2, CH73-233A22.6, S5AR 2, SRD5A2, Srd5a2, SRD5alpha2, wu:fk70d02, zgc:109942, zgc:112208, zgc:112455

Protein level used designations for Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2)

  • 3-oxo-5-alpha-steroid 4-dehydrogenase 2
  • 5 alpha-SR2
  • S5AR 2
  • SR type 2
  • steroid 5-alpha-reductase 2
  • type II 5-alpha reductase
  • steroid 5 alpha reductase type2
  • prostatic steroid 5-alpha-reductase type II
  • steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
  • steroid-5-alpha-reductase alpha polypeptide 2
  • steroid-5-alpha-reductase, alpha polypeptide 2b
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