STAT3 Products
(Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
Categories
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
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Featured STAT3 Categories
STAT3 Antibodies
High quality antibodies with extensive validation data.
STAT3 ELISA Kits
Reliable ELISA kits for a wide range of species.
STAT3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended STAT3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), ICC
Validations
- (1)
- (8)
- (1)
Cat. No.
ABIN2855865
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (3)
- (7)
Cat. No.
ABIN6265317
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IP, IF, ICC
Validations
- (3)
- (9)
Cat. No.
ABIN6256411
Quantity
100 μL
Datasheet
Datasheet
Recommended STAT3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Semi-Quantitative Cell ELISA
Validations
- (3)
- (6)
Cat. No.
ABIN1981839
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (2)
- (6)
Cat. No.
ABIN625245
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (1)
- (3)
Cat. No.
ABIN1981729
Quantity
96 tests
Datasheet
Datasheet
Recommended STAT3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (2)
- (1)
Cat. No.
ABIN1321594
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125094
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321596
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our STAT3 products
: "Tibetan medicine Ershiwuwei Lvxue Pill attenuates collagen-induced arthritis via inhibition of JAK2/STAT3 signaling pathway." in: Journal of ethnopharmacology, Vol. 270, pp. 113820, (2021) (PubMed).: "Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin." in: International journal of pharmaceutics, Vol. 606, pp. 120872, (2021) (PubMed).
: "Bazedoxifene Plays a Protective Role against Inflammatory Injury of Endothelial Cells by Targeting CD40." in: Cardiovascular therapeutics, Vol. 2020, pp. 1795853, (2021) (PubMed).
: "Oleacein and Foam Cell Formation in Human Monocyte-Derived Macrophages: A Potential Strategy Against Early and Advanced Atherosclerotic Lesions." in: Pharmaceuticals (Basel, Switzerland), Vol. 13, Issue 4, (2020) (PubMed).
: "Serum ERK1/2 proteins fluctuating with HBV infection report frequency of viral-specific CD8+ T cells and predict IFNα therapeutic effect in chronic hepatitis B patients." in: Clinical immunology (Orlando, Fla.), Vol. 219, pp. 108570, (2020) (PubMed).
: "CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling." in: Cell death & disease, Vol. 11, Issue 4, pp. 234, (2020) (PubMed).
: "Bazedoxifene inhibits PDGF-BB induced VSMC phenotypic switch via regulating the autophagy level." in: Life sciences, Vol. 259, pp. 118397, (2020) (PubMed).
: "Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p ..." in: Journal of experimental & clinical cancer research : CR, Vol. 38, Issue 1, pp. 62, (2019) (PubMed).
: "Opa interacting protein 5 promotes metastasis of nasopharyngeal carcinoma cells by promoting EMT via modulation of JAK2/STAT3 signal." in: European review for medical and pharmacological sciences, Vol. 23, Issue 2, pp. 613-621, (2019) (PubMed).
: "STAT3, STAT5A, STAT5B and STAT6 proteins are overexpressed in human basal cell carcinoma." in: Clinical and experimental dermatology, (2019) (PubMed).
Synonyms and alternative names related to STAT3
signal transducer and activator of transcription 3 (STAT3), signal transduction and activation of transcription 3 (stat3), signal transducer and activator of transcription 3 (stat3), signal transducer and activator of transcription 3 (Stat3), signal transducer and activator of transcription 3, gene 1 L homeolog (stat3.1.L), signal transducer and activator of transcription 3 (acute-phase response factor) (stat3), 1110034C02Rik, Aprf, APRF, aprf, AW109958, HIES, hies, stat3, wu:fc15d02, wu:fl59g06, Xstat3, z-Stat3Protein level used designations for STAT3
- signal transducer and activator of transcription 3 (acute-phase response factor)
- signal transducer and activator of transcription 3
- signal transduction and activation of transcription 3
- Signal transducer and activator of transcription 3
- signal transducer and activator of transcription 3-like
- acute phase response factor
- acute-phase response factor
- DNA-binding protein APRF
- Protein Stat3
- signal transducer and activator of transcription 3.1
- stat 3
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