STAT2 Products
(Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))
Categories
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
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Featured STAT2 Categories
STAT2 Antibodies
High quality antibodies with extensive validation data.
STAT2 ELISA Kits
Reliable ELISA kits for a wide range of species.
STAT2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended STAT2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7434083
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7443368
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (6)
Cat. No.
ABIN738246
Quantity
100 μL
Datasheet
Datasheet
Recommended STAT2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (3)
Cat. No.
ABIN5691024
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970214
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970213
Quantity
96 tests
Datasheet
Datasheet
Recommended STAT2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321592
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7394858
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7406047
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our STAT2 products
: "STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α." in: Scientific reports, Vol. 6, pp. 38336, (2018) (PubMed).: "Porcine Deltacoronavirus nsp5 Antagonizes Type I Interferon Signaling by Cleaving STAT2." in: Journal of virology, Vol. 91, Issue 10, (2017) (PubMed).
: "JAK3 as an Emerging Target for Topical Treatment of Inflammatory Skin Diseases." in: PloS one, Vol. 11, Issue 10, pp. e0164080, (2017) (PubMed).
: "The detrimental effects of IFN-α on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 4457-69, (2010) (PubMed).
: "Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2." in: The Journal of biological chemistry, Vol. 283, Issue 18, pp. 12034-42, (2008) (PubMed).
: "Suppression of interferon (IFN)-inducible genes and IFN-mediated functional responses in BCR-ABL-expressing cells." in: The Journal of biological chemistry, Vol. 283, Issue 16, pp. 10793-803, (2008) (PubMed).
: "Upregulation of a small subset of genes drives type I interferon-induced antiviral memory." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 27, Issue 8, pp. 653-64, (2007) (PubMed).
: "Stats: multifaceted regulators of transcription." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 25, Issue 12, pp. 733-44, (2005) (PubMed).
: "Functional relevance of the conserved DNA-binding domain of STAT2." in: The Journal of biological chemistry, Vol. 280, Issue 13, pp. 13029-36, (2005) (PubMed).
: "STAT2 nuclear trafficking." in: The Journal of biological chemistry, Vol. 279, Issue 38, pp. 39199-206, (2004) (PubMed).
Synonyms and alternative names related to STAT2
signal transducer and activator of transcription 2 (stat2), signal transducer and activator of transcription 2 (STAT2), AGAP000099-PA (STAT2), signal transducer and activator of transcription 2 (Stat2), 1600010G07Rik, AW496480, ISGF-3, p113, P113, stat2, STAT113, wu:fj84d07Protein level used designations for STAT2
- fj84d07
- signal transducer and activator of transcription 2
- signal transducer and activator of transcription (AGAP000099-PA)
- interferon alpha induced transcriptional activator
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