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SRRT Products

(Serrate RNA Effector Molecule Homolog (SRRT))

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Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA)\; however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).

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Featured SRRT Categories

SRRT Antibodies

High quality antibodies with extensive validation data.

SRRT Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SRRT Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF
Validations
  • (4)
Cat. No. ABIN526827
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN2613482
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7169355
Quantity 100 μL
Datasheet Datasheet

Recommended SRRT Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1345737
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2714949
Quantity 20 μg
Datasheet Datasheet
Reactivity Chinese Hamster
Source Yeast
Validations
Cat. No. ABIN1635251
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our SRRT products

Ke, Pang, Chen, Zhang, Wang, Zhu, Mao, Hu, Zhang, Cui: "Knockdown of arsenic resistance protein 2 inhibits human glioblastoma cell proliferation through the MAPK/ERK pathway." in: Oncology reports, Vol. 40, Issue 6, pp. 3313-3322, (2019) (PubMed).

OSullivan, Christie, Pienaar, Gambling, Nickerson, Alford, Chow, Howard: "Mutagenesis of ARS2 Domains To Assess Possible Roles in Cell Cycle Progression and MicroRNA and Replication-Dependent Histone mRNA Biogenesis." in: Molecular and cellular biology, Vol. 35, Issue 21, pp. 3753-67, (2015) (PubMed).

Gruber, Olejniczak, Yong, La Rocca, Dreyfuss, Thompson: "Ars2 promotes proper replication-dependent histone mRNA 3' end formation." in: Molecular cell, Vol. 45, Issue 1, pp. 87-98, (2012) (PubMed).

Synonyms and alternative names related to SRRT

Arsenic resistance protein 2 (Ars2), serrate, RNA effector molecule S homeolog (srrt.S), serrate, RNA effector molecule (SRRT), serrate RNA effector molecule homolog (Arabidopsis) (Srrt), serrate, RNA effector molecule (Srrt), serrate RNA effector molecule homolog (Arabidopsis) (srrt), 2810019G02Rik, anon-WO0118547.166, ars2, ARS2, Ars2, ars2-A, ASR2, Asr2, ASR2A, ASR2B, ASR2C, ASR2D, CG7843, CHUNP6881, Dmel\\CG7843, MGC92060, serrate, zgc:92060

Protein level used designations for SRRT

  • Ars2-PA
  • Ars2-PC
  • Ars2-PD
  • Ars2-PE
  • Ars2-PF
  • Ars2-PG
  • CG7843-PA
  • CG7843-PC
  • CG7843-PD
  • CG7843-PE
  • CG7843-PF
  • CG7843-PG
  • Arsenite-resistance protein 2-A
  • serrate RNA effector molecule homolog A
  • arsenate resistance protein 2
  • arsenate resistance protein ARS2
  • arsenite resistance protein
  • arsenite-resistance protein 2
  • serrate RNA effector molecule homolog
  • Arsenite-resistance protein 2
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