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SRPK2 Products

(SFRS Protein Kinase 2 (SRPK2))

Categories

Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up- regulation. Plays an essential role in splicesomal B complex formation via the phosphorylation of DDX23/PRP28.

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Featured SRPK2 Categories

SRPK2 Antibodies

High quality antibodies with extensive validation data.

SRPK2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SRPK2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7170677
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN6265291
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN391795
Quantity 400 μL
Datasheet Datasheet

Recommended SRPK2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1321346
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1321348
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1321350
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our SRPK2 products

Cantrell: "Phosphoinositide 3-kinase signalling pathways." in: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, (2001) (PubMed).

Blume-Jensen, Hunter: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, (2001) (PubMed).

Jhiang: "The RET proto-oncogene in human cancers." in: Oncogene, Vol. 19, Issue 49, pp. 5590-7, (2000) (PubMed).

Wang, Lin, Dyck, Yeakley, Songyang, Cantley, Fu: "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells." in: The Journal of cell biology, Vol. 140, Issue 4, pp. 737-50, (1998) (PubMed).

Synonyms and alternative names related to SRPK2

SRSF protein kinase 2 (SRPK2), serine/arginine-rich protein specific kinase 2 (Srpk2), SRSF protein kinase 2 (Srpk2), SRSF protein kinase 2 (srpk2), SRSF protein kinase 2 L homeolog (srpk2.L), AW226533, AW492537, AW547358, mSRPK2, SFRSK2, sfrsk2, srpk2, srpk2-b, srpk2b, Wbp6

Protein level used designations for SRPK2

  • SFRS protein kinase 2
  • SR protein kinase 2
  • SR-protein-specific kinase 2
  • serine kinase SRPK2
  • serine/arginine-rich protein-specific kinase 2
  • serine/arginine-rich splicing factor kinase 2
  • serine/threonine-protein kinase SRPK2
  • SRSF protein kinase 2
  • WW domain binding protein 6
  • serine/arginine-rich protein specific kinase 2
  • serine/threonine-protein kinase SRPK2-like
  • SFRS protein kinase 2b
  • SRSF protein kinase 2 L homeolog
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