SRPK2 Products
(SFRS Protein Kinase 2 (SRPK2))
Categories
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up- regulation. Plays an essential role in splicesomal B complex formation via the phosphorylation of DDX23/PRP28.
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Featured SRPK2 Categories
SRPK2 Antibodies
High quality antibodies with extensive validation data.
SRPK2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SRPK2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7170677
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN6265291
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN391795
Quantity
400 μL
Datasheet
Datasheet
Recommended SRPK2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321346
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321348
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321350
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our SRPK2 products
: "Phosphoinositide 3-kinase signalling pathways." in: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, (2001) (PubMed).: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, (2001) (PubMed).
: "The RET proto-oncogene in human cancers." in: Oncogene, Vol. 19, Issue 49, pp. 5590-7, (2000) (PubMed).
: "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells." in: The Journal of cell biology, Vol. 140, Issue 4, pp. 737-50, (1998) (PubMed).
Synonyms and alternative names related to SRPK2
SRSF protein kinase 2 (SRPK2), serine/arginine-rich protein specific kinase 2 (Srpk2), SRSF protein kinase 2 (Srpk2), SRSF protein kinase 2 (srpk2), SRSF protein kinase 2 L homeolog (srpk2.L), AW226533, AW492537, AW547358, mSRPK2, SFRSK2, sfrsk2, srpk2, srpk2-b, srpk2b, Wbp6Protein level used designations for SRPK2
- SFRS protein kinase 2
- SR protein kinase 2
- SR-protein-specific kinase 2
- serine kinase SRPK2
- serine/arginine-rich protein-specific kinase 2
- serine/arginine-rich splicing factor kinase 2
- serine/threonine-protein kinase SRPK2
- SRSF protein kinase 2
- WW domain binding protein 6
- serine/arginine-rich protein specific kinase 2
- serine/threonine-protein kinase SRPK2-like
- SFRS protein kinase 2b
- SRSF protein kinase 2 L homeolog
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