SREBF1 Products
(Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))
Categories
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured SREBF1 Categories
SREBF1 Antibodies
High quality antibodies with extensive validation data.
SREBF1 ELISA Kits
Reliable ELISA kits for a wide range of species.
SREBF1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SREBF1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
Cat. No.
ABIN7170778
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), FACS
Validations
- (4)
Cat. No.
ABIN652680
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (4)
Cat. No.
ABIN562994
Quantity
100 μg
Datasheet
Datasheet
Recommended SREBF1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6975978
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6976130
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380856
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended SREBF1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321306
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7418251
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3113513
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SREBF1 products
: "Prolyl Endopeptidase Gene Disruption Improves Gut Dysbiosis and Non-alcoholic Fatty Liver Disease in Mice Induced by a High-Fat Diet." in: Frontiers in cell and developmental biology, Vol. 9, pp. 628143, (2021) (PubMed).: "14-Deoxy-11,12-didehydroandrographolide suppresses adipogenesis of 3 T3-L1 preadipocytes by inhibiting CCAAT/enhancer-binding protein β activation and AMPK-mediated mitotic clonal expansion." in: Toxicology and applied pharmacology, Vol. 359, pp. 82-90, (2019) (PubMed).
: "Perilipin 5 promotes hepatic steatosis in dairy cows through increasing lipid synthesis and decreasing very low density lipoprotein assembly." in: Journal of dairy science, Vol. 102, Issue 1, pp. 833-845, (2019) (PubMed).
: "Sterol 12α-hydroxylase Aggravates Dyslipidemia by Activating the Ceramide/mTORC1/SREBP1C Pathway via FGF21 and FGF15." in: Gene expression, (2019) (PubMed).
: "Benzyl Isothiocyanate and Phenethyl Isothiocyanate Inhibit Adipogenesis and Hepatosteatosis in Mice with Obesity Induced by a High-Fat Diet." in: Journal of agricultural and food chemistry, Vol. 67, Issue 25, pp. 7136-7146, (2019) (PubMed).
: "Low abundance of mitofusin 2 in dairy cows with moderate fatty liver is associated with alterations in hepatic lipid metabolism." in: Journal of dairy science, Vol. 102, Issue 8, pp. 7536-7547, (2019) (PubMed).
: "Hepatic Forkhead Box Protein A3 Regulates ApoA-I (Apolipoprotein A-I) Expression, Cholesterol Efflux, and Atherogenesis." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 39, Issue 8, pp. 1574-1587, (2019) (PubMed).
: "Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells." in: Cell death & disease, Vol. 10, Issue 7, pp. 537, (2019) (PubMed).
: "Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells." in: Frontiers in pharmacology, Vol. 10, pp. 709, (2019) (PubMed).
: "Non-alcoholic Fatty Liver Disease Induced by Perinatal Exposure to Bisphenol a Is Associated With Activated mTOR and TLR4/NF-κB Signaling Pathways in Offspring Rats." in: Frontiers in endocrinology, Vol. 10, pp. 620, (2019) (PubMed).
Synonyms and alternative names related to SREBF1
sterol regulatory element binding transcription factor 1 (SREBF1), sterol regulatory element binding transcription factor 1 (Srebf1), sterol regulatory element binding transcription factor 1 L homeolog (srebf1.L), sterol regulatory element binding protein-1 (SREBP-1), sterol regulatory element binding transcription factor 1 (srebf1), Sterol regulatory element Binding Protein (sbp-1), ADD-1, ADD1, bHLHd1, D630008H06, SCREBP1, SREBF1, SREBP-1, SREBP-1a, SREBP-1c, SREBP-1C, SREBP1, Srebp1, srebp1, SREBP1cProtein level used designations for SREBF1
- SREBP-1
- class D basic helix-loop-helix protein 1
- sterol regulatory element-binding protein 1
- adipocyte determination- and differentiation-dependent factor 1
- sterol regulatory element binding protein 1
- adipocyte determination and differentiation-dependent factor 1
- sterol regulatory binding transcription factor 1
- sterol regulatory element-binding transcription factor 1
- sterol regulatory element binding-protein 1
- sterol regulatory element binding transcription factor 1
- sterol response element binding protein 1
- similar to sterol regulatory element binding transcription factor 1 isoform b
- sterol regulatory element binding protein-1
- SREBP1
- sterol regulatory element-binding protein 1-like
- Sterol regulatory element Binding Protein family member (sbp-1)
- Sterol regulatory element-binding transcription factor 1
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