SPTLC1 Products
(serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1))
Categories
Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
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Featured SPTLC1 Categories
SPTLC1 Antibodies
High quality antibodies with extensive validation data.
SPTLC1 ELISA Kits
Reliable ELISA kits for a wide range of species.
SPTLC1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SPTLC1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p)
Validations
- (6)
Cat. No.
ABIN3187765
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7436414
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7168895
Quantity
100 μL
Datasheet
Datasheet
Recommended SPTLC1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970110
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959376
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5658719
Quantity
96 tests
Datasheet
Datasheet
Recommended SPTLC1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321282
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7399220
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3131665
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SPTLC1 products
: "Transcriptional Differences in Lipid-Metabolizing Enzymes in Murine Sebocytes Derived from Sebaceous Glands of the Skin and Preputial Glands." in: International journal of molecular sciences, Vol. 22, Issue 21, (2021) (PubMed).: "Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells." in: The Journal of biological chemistry, Vol. 290, Issue 1, pp. 90-8, (2015) (PubMed).
: "Serine palmitoyltransferase subunit 1 is present in the endoplasmic reticulum, nucleus and focal adhesions, and functions in cell morphology." in: Biochimica et biophysica acta, Vol. 1791, Issue 8, pp. 746-56, (2009) (PubMed).
: "Apoptotic sphingolipid signaling by ceramides in lung endothelial cells." in: American journal of respiratory cell and molecular biology, Vol. 38, Issue 6, pp. 639-46, (2008) (PubMed).
: "Permeability barrier disruption increases the level of serine palmitoyltransferase in human epidermis." in: The Journal of investigative dermatology, Vol. 119, Issue 5, pp. 1048-52, (2002) (PubMed).
: "Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I." in: Nature genetics, Vol. 27, Issue 3, pp. 309-12, (2001) (PubMed).
: "Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum." in: Brain research, Vol. 909, Issue 1-2, pp. 187-93, (2001) (PubMed).
: "A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis." in: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32108-14, (1998) (PubMed).
: "Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis." in: European journal of biochemistry / FEBS, Vol. 249, Issue 1, pp. 239-47, (1997) (PubMed).
Synonyms and alternative names related to SPTLC1
serine palmitoyltransferase 1 (SPT1), serine palmitoyltransferase 1 (AFUA_6G00300), Serine palmitoyltransferase 1 (PAS_FragB_0040), serine palmitoyltransferase long chain base subunit 1 (SPTLC1), serine palmitoyltransferase, long chain base subunit 1 (sptlc1), serine palmitoyltransferase, long chain base subunit 1 L homeolog (sptlc1.L), serine palmitoyltransferase, long chain base subunit 1 (Sptlc1), serine palmitoyltransferase long chain base subunit 1 (Sptlc1), Afu6g00300, ATSPT1, AW552086, C77762, E030036H05, HSAN1, HSN1, LBC1, LCB1, Lcb1, RGD1306617, SERINE PALMITOYLTRANSFERASE 1, serine palmitoyltransferase 1, SPT1, Spt1, SPTI, wu:fc75h04, wu:fp41c08, zgc:112247Protein level used designations for SPTLC1
- Serine palmitoyltransferase 1
- LCB 1
- SPT 1
- long chain base biosynthesis protein 1
- serine C-palmitoyltransferase
- serine palmitoyltransferase 1
- serine-palmitoyl-CoA transferase 1
- fc75h04
- fp41c08
- SPT1
- serine palmitoyltransferase subunit 1
- Long chain base biosynthesis protein 1
- Serine-palmitoyl-CoA transferase 1
- serine palmitoyltransferase LCB1 subunit
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