SPRY2 Products
(Sprouty Homolog 2 (SPRY2))
Categories
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008].
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Featured SPRY2 Categories
SPRY2 Antibodies
High quality antibodies with extensive validation data.
SPRY2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SPRY2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (3)
- (6)
Cat. No.
ABIN564439
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7170654
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN7270554
Quantity
100 μL
Datasheet
Datasheet
Recommended SPRY2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6232462
Quantity
96 tests
Datasheet
Datasheet
Recommended SPRY2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321263
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7405816
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7405819
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our SPRY2 products
: "Induction of Resistance to BRAF Inhibitor Is Associated with the Inability of Spry2 to Inhibit BRAF-V600E Activity in BRAF Mutant Cells." in: Biomolecules & therapeutics, Vol. 23, Issue 4, pp. 320-6, (2015) (PubMed).: "Sprouty2 suppresses the inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes through regulating the Raf/ERK and PTEN/AKT signals." in: Molecular immunology, Vol. 67, Issue 2 Pt B, pp. 532-9, (2015) (PubMed).
: "SPROUTY2 is a ?-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer." in: Oncogene, Vol. 33, Issue 15, pp. 1975-85, (2014) (PubMed).
: "Initial report on differential expression of sprouty proteins 1 and 2 in human epithelial ovarian cancer cell lines." in: Journal of oncology, Vol. 2012, pp. 373826, (2012) (PubMed).
: "SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity." in: Oncogene, Vol. 29, Issue 34, pp. 4800-13, (2010) (PubMed).
: "Clostridium perfringens Keratitis Leading to Blinding Panophthalmitis." in: Cornea, Vol. 27, Issue 10, pp. 1200-3, (2008) (PubMed).
: "Regulation of vascular smooth muscle cell proliferation and migration by human sprouty 2." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 25, Issue 3, pp. 533-8, (2005) (PubMed).
: "Cerebrovascular and carotid artery disease." in: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, Vol. 92, Issue 3, pp. 253-6, (2001) (PubMed).
Synonyms and alternative names related to SPRY2
sprouty RTK signaling antagonist 2 (spry2), sprouty RTK signaling antagonist 2 (SPRY2), sprouty RTK signaling antagonist 2 S homeolog (spry2.S), sprouty homolog 2 (Drosophila) (Spry2), sprouty RTK signaling antagonist 2 (Spry2), hspry2, hSPRY2, sprouty-2, sprouty2, wu:fk66h11, wu:fk93e11, Xsprouty2, xspry2, Xtsprouty2, zgc:110440Protein level used designations for SPRY2
- protein sprouty homolog 2
- sprouty 2
- spry-2
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