SPPL2B Products
(Signal Peptide Peptidase-Like 2B (SPPL2B))
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This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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SPPL2B Antibodies
High quality antibodies with extensive validation data.
Recommended SPPL2B Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN634985
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rat
Application
WB, IHC
Validations
- (1)
- (3)
Cat. No.
ABIN2782090
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Human
Application
WB, IHC, IHC (p)
Validations
- (2)
Cat. No.
ABIN6738138
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our SPPL2B products
: "A protease-independent function for SPPL3 in NFAT activation." in: Molecular and cellular biology, Vol. 35, Issue 2, pp. 451-67, (2014) (PubMed).: "BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer's disease." in: Neurobiology of aging, Vol. 35, Issue 7, pp. 1596-604, (2014) (PubMed).
: "Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins." in: The Journal of biological chemistry, Vol. 279, Issue 49, pp. 50790-8, (2004) (PubMed).
: "Novel class of polytopic proteins with domains associated with putative protease activity." in: Biochemistry. Biokhimii?a, Vol. 67, Issue 7, pp. 826-35, (2002) (PubMed).
: "Identification of signal peptide peptidase, a presenilin-type aspartic protease." in: Science (New York, N.Y.), Vol. 296, Issue 5576, pp. 2215-8, (2002) (PubMed).
: "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 7, Issue 2, pp. 143-50, (2000) (PubMed).
Synonyms and alternative names related to SPPL2B
signal peptide peptidase-like 2 (sppl2), signal peptide peptidase like 2B (sppl2b), signal peptide peptidase like 2B S homeolog (sppl2b.S), signal peptide peptidase like 2B (SPPL2B), signal peptide peptidase like 2B (Sppl2b), signal peptide peptidase-like 2B (Sppl2b), 3110056O03Rik, AW550292, IMP-4, IMP4, MGC147524, PSH4, PSL1, RGD1308556, SPPL2B, wu:fc16e01, wu:fc85d12, zgc:136525Protein level used designations for SPPL2B
- signal peptide peptidase-like 2B
- signal peptide peptidase-like protein 2
- SPP-like 2B
- protein SPP-like 2B
- protein SPPL2b
- intramembrane protease 4
- presenilin homologous protein 4
- presenilin-like protein 1
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