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SPPL2A Products

(Signal Peptide Peptidase-Like 2A (SPPL2A))

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This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Feb 2012].

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Featured SPPL2A Categories

SPPL2A Antibodies

High quality antibodies with extensive validation data.

SPPL2A Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SPPL2A Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB, IHC, IF
Validations
  • (3)
Cat. No. ABIN7169623
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN390295
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (2)
Cat. No. ABIN2565915
Quantity 100 μg
Datasheet Datasheet

Recommended SPPL2A ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6221477
Quantity 96 tests
Datasheet Datasheet

Recommended SPPL2A Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1321237
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our SPPL2A products

Friedmann, Lemberg, Weihofen, Dev, Dengler, Rovelli, Martoglio: "Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins." in: The Journal of biological chemistry, Vol. 279, Issue 49, pp. 50790-8, (2004) (PubMed).

Grigorenko, Moliaka, Korovaitseva, Rogaev: "Novel class of polytopic proteins with domains associated with putative protease activity." in: Biochemistry. Biokhimii?a, Vol. 67, Issue 7, pp. 826-35, (2002) (PubMed).

Weihofen, Binns, Lemberg, Ashman, Martoglio: "Identification of signal peptide peptidase, a presenilin-type aspartic protease." in: Science (New York, N.Y.), Vol. 296, Issue 5576, pp. 2215-8, (2002) (PubMed).

Synonyms and alternative names related to SPPL2A

signal peptide peptidase-like 2A (Sppl2a), signal peptide peptidase like 2A (SPPL2A), signal peptide peptidase like 2A (sppl2a), Signal peptide peptidase-like 2A (psl2), signal peptide peptidase like 2A (Sppl2a), 2010106G01Rik, C130089K23Rik, IMP3, LOC453430, LOC100231183, PSL2, RGD1563001, SPPL2A

Protein level used designations for SPPL2A

  • signal peptide peptidase-like 2A
  • Signal peptide peptidase-like 2A
  • IMP-3
  • SPP-like 2A
  • intramembrane cleaving protease
  • intramembrane protease 3
  • presenilin-like protein 2
  • SPP-like 2A protein
  • protein SPPL2a
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