SPHK2 Products
(Sphingosine Kinase 2 (SPHK2))
Categories
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].
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Featured SPHK2 Categories
SPHK2 Antibodies
High quality antibodies with extensive validation data.
SPHK2 ELISA Kits
Reliable ELISA kits for a wide range of species.
SPHK2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SPHK2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
- (4)
Cat. No.
ABIN391349
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (8)
- (2)
Cat. No.
ABIN391348
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (3)
Cat. No.
ABIN949506
Quantity
100 μL
Datasheet
Datasheet
Recommended SPHK2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381512
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5592624
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN456114
Quantity
96 tests
Datasheet
Datasheet
Recommended SPHK2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321164
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321166
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5509153
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our SPHK2 products
: "Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain." in: Cell death & disease, Vol. 8, Issue 7, pp. e2912, (2018) (PubMed).: "Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD." in: PLoS ONE, Vol. 12, Issue 11, pp. e0179577, (2017) (PubMed).
: "Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase 2 and FAK/AKT pathway." in: Experimental and molecular pathology, Vol. 100, Issue 1, pp. 51-8, (2016) (PubMed).
: "Hair Cell Loss Induced by Sphingosine and a Sphingosine Kinase Inhibitor in the Rat Cochlea." in: Neurotoxicity research, Vol. 29, Issue 1, pp. 35-46, (2016) (PubMed).
: "Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720." in: Journal of leukocyte biology, Vol. 100, Issue 1, pp. 195-202, (2016) (PubMed).
: "Sphingosine-1-phosphate is involved in the occlusive arteriopathy of pulmonary arterial hypertension." in: Pulmonary circulation, Vol. 6, Issue 3, pp. 369-80, (2016) (PubMed).
: "Down-regulation of Sphk2 suppresses bladder cancer progression." in: Tumour biology, (2015) (PubMed).
: "Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 29, Issue 11, pp. 4654-69, (2015) (PubMed).
: "Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons." in: The Journal of biological chemistry, Vol. 289, Issue 30, pp. 20845-57, (2014) (PubMed).
: "Inducible IL-33 expression by mast cells is regulated by a calcium-dependent pathway." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 7, pp. 3421-9, (2012) (PubMed).
Synonyms and alternative names related to SPHK2
Sphingosine kinase (sphK2), sphk2 (sphK2), Sphingosine kinase 2 (Sk2), sphingosine kinase 2 (SPHK2), sphingosine kinase 2 (Sphk2), C76851, CG2159, CG32484, DKFZp469F224, Dmel\\CG32484, SK-2, SK2, sk2, SK 2, Sphk2, SPK-2, SPK 2Protein level used designations for SPHK2
- Sphingosine kinase
- sphk2
- sphingosine kinase 2
- CG32484-PA
- Sk2-PA
- sphingosine kinase
- sphingosine kinase II
- sphingosine kinase 2-like
- sphingosine kinase type 2
- SK 2
- SPK 2
- Spk2, Sk2
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