SPHK1 Products
(Sphingosine Kinase 1 (SPHK1))
Categories
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
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Featured SPHK1 Categories
SPHK1 Antibodies
High quality antibodies with extensive validation data.
SPHK1 ELISA Kits
Reliable ELISA kits for a wide range of species.
SPHK1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SPHK1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
- (22)
- (5)
Cat. No.
ABIN391346
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (11)
- (5)
Cat. No.
ABIN522355
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
- (4)
Cat. No.
ABIN391345
Quantity
400 μL
Datasheet
Datasheet
Recommended SPHK1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959677
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN5510666
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4884635
Quantity
96 tests
Datasheet
Datasheet
Recommended SPHK1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321162
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321160
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells
Validations
- (1)
Cat. No.
ABIN7317043
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our SPHK1 products
: "Sphingosine kinase 1 expression enhances colon tumor growth." in: Journal of translational medicine, Vol. 15, Issue 1, pp. 120, (2018) (PubMed).: "Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain." in: Cell death & disease, Vol. 8, Issue 7, pp. e2912, (2018) (PubMed).
: "Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD." in: PLoS ONE, Vol. 12, Issue 11, pp. e0179577, (2017) (PubMed).
: "Overexpression of sphingosine kinase 1 is predictive of poor prognosis in human breast cancer." in: Oncology letters, Vol. 14, Issue 1, pp. 63-72, (2017) (PubMed).
: "Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma." in: Anticancer research, Vol. 37, Issue 10, pp. 5399-5405, (2017) (PubMed).
: "Sphingosine kinase 1 mediates AGEs-induced fibronectin upregulation in diabetic nephropathy." in: Oncotarget, Vol. 8, Issue 45, pp. 78660-78676, (2017) (PubMed).
: "Hair Cell Loss Induced by Sphingosine and a Sphingosine Kinase Inhibitor in the Rat Cochlea." in: Neurotoxicity research, Vol. 29, Issue 1, pp. 35-46, (2016) (PubMed).
: "Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720." in: Journal of leukocyte biology, Vol. 100, Issue 1, pp. 195-202, (2016) (PubMed).
: "Sphingosine-1-phosphate is involved in the occlusive arteriopathy of pulmonary arterial hypertension." in: Pulmonary circulation, Vol. 6, Issue 3, pp. 369-80, (2016) (PubMed).
: "Immunoliposome-mediated drug delivery to Plasmodium-infected and non-infected red blood cells as a dual therapeutic/prophylactic antimalarial strategy." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 210, pp. 217-29, (2016) (PubMed).
Synonyms and alternative names related to SPHK1
Sphingosine kinase 1 (Sk1), sphingosine kinase 1 (SPHK1), sphingosine kinase 1 L homeolog (sphk1.L), sphingosine kinase 1 (Sphk1), 1110006G24Rik, CG1747, Dmel\\CG1747, F18E5.160, F18E5_160, SK1, Sk1, sphingosine kinase 1, SPHK, Sphk1, SPHK1, Spk1Protein level used designations for SPHK1
- CG1747-PA
- CG1747-PB
- Sk1-PA
- Sk1-PB
- sphingosine kinase 1
- sphingosine kinase I
- SK 1
- SPK 1
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