Spartan Products
(Chromosome 1 Open Reading Frame 124 (C1orf124))
Categories
Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (By similarity). {ECO:0000250}.
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Recommended Spartan Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7252330
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (1)
Cat. No.
ABIN7170650
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN6750700
Quantity
100 μL
Datasheet
Datasheet
Recommended Spartan Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1347305
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3131201
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3095643
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our Spartan products
: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).: "DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks." in: Nature structural & molecular biology, Vol. 19, Issue 11, pp. 1084-92, (2012) (PubMed).
Synonyms and alternative names related to Spartan
SprT-like N-terminal domain (sprtn), SprT-like N-terminal domain (SPRTN), c1orf124, C1orf124, C28H1orf124, DDDL1880, dJ876B10.3, DVC1, PRO4323, SpartanProtein level used designations for Spartan
- Protein with SprT-like domain at the N terminus
- sprT-like domain-containing protein Spartan
- DNA damage protein targeting VCP
- DNA damage-targeting VCP (p97) adaptor
- SprT-like domain at the N terminus
- protein with SprT-like domain at the N terminus
- zinc finger RAD18 domain-containing protein C1orf124
- spartan
- zinc finger RAD18 domain-containing protein C1orf124 homolog
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