SPANXC Products
(SPANX Family, Member C (SPANXC))
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Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy. [provided by RefSeq, Jul 2008].
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Featured SPANXC Categories
SPANXC Antibodies
High quality antibodies with extensive validation data.
Recommended SPANXC Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC (p), IF (p), IF (cc), IHC (fro)
Validations
- (2)
Cat. No.
ABIN721675
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (1)
Cat. No.
ABIN7170464
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB
Validations
- (1)
Cat. No.
ABIN129672
Quantity
100 μg
Datasheet
Datasheet
Recommended SPANXC ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6207624
Quantity
96 tests
Datasheet
Datasheet
Latest Publications for our SPANXC products
: "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27." in: Genome research, Vol. 15, Issue 11, pp. 1477-86, (2005) (PubMed).: "Genomic organization, incidence, and localization of the SPAN-x family of cancer-testis antigens in melanoma tumors and cell lines." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 1 Pt 1, pp. 101-12, (2004) (PubMed).
: "The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 9, pp. 3077-82, (2004) (PubMed).
: "The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines." in: Gene, Vol. 309, Issue 2, pp. 125-33, (2003) (PubMed).
Synonyms and alternative names related to SPANXC
SPANX family member C (SPANXC), C, CT11.3, CTp11, SPANX-CProtein level used designations for SPANXC
- SPAN-Xc protein
- cancer-testis-associated protein CTp11
- cancer/testis antigen 11.3
- cancer/testis antigen family 11, member 3
- cancer/testis-associated protein CTp11
- cancer/testis-associated protein of 11 kD
- nuclear-associated protein SPAN-Xc
- sperm protein associated with the nucleus on the X chromosome C
- sperm protein associated with the nucleus, X chromosome, family member C
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