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SPAM1 Products

(Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1))
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1\; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

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Featured SPAM1 Categories

SPAM1 Antibodies

High quality antibodies with extensive validation data.

SPAM1 ELISA Kits

Reliable ELISA kits for a wide range of species.

SPAM1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SPAM1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, IHC
Validations
  • (6)
Cat. No. ABIN1513554
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN6265252
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (6)
  • (1)
Cat. No. ABIN562973
Quantity 50 μL
Datasheet Datasheet

Recommended SPAM1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959661
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959662
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6974834
Quantity 96 tests
Datasheet Datasheet

Recommended SPAM1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1321072
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN6964321
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1321071
Quantity 25 μg
Datasheet Datasheet

Latest Publications for our SPAM1 products

Panogeorgou, Tserbini, Filou, Vynios, Naxakis, Papadas, Goumas, Mastronikolis: "Hyaluronan synthases and hyaluronidases in nasal polyps." in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, Vol. 273, Issue 7, pp. 1801-8, (2016) (PubMed).

Li, Yang, Chen, Guan, Du, Guo, Wang, Wang, Li, Jiang, Li: "Expression of a functional recombinant oleosin-human hyaluronidase hPH-20 fusion in Arabidopsis thaliana." in: Protein expression and purification, Vol. 103, pp. 23-7, (2014) (PubMed).

Redgrove, Anderson, McLaughlin, OBryan, Aitken, Nixon: "Investigation of the mechanisms by which the molecular chaperone HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition." in: Molecular human reproduction, Vol. 19, Issue 3, pp. 120-35, (2013) (PubMed).

Kaessler, Olgen, Jose: "Autodisplay of catalytically active human hyaluronidase hPH-20 and testing of enzyme inhibitors." in: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Vol. 42, Issue 1-2, pp. 138-47, (2010) (PubMed).

Monzón, Manzanares, Schmid, Casalino-Matsuda, Forteza: "Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells." in: American journal of respiratory cell and molecular biology, Vol. 39, Issue 3, pp. 289-95, (2008) (PubMed).

in: (PubMed).

Synonyms and alternative names related to SPAM1

sperm adhesion molecule 1 (Spam1), sperm adhesion molecule 1 (SPAM1), sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog (spam1.L), sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), sperm adhesion molecule 1 (spam1), AV039194, HYA1, HYAL1, HYAL3, HYAL5, im:6902904, Ph-20, PH-20, PH20, SPAG15, Spam, spam1, XEH1, zgc:158668

Protein level used designations for SPAM1

  • hyal-PH20
  • hyaluronidase PH-20
  • hyaluronoglucosaminidase PH-20
  • sperm surface protein PH-20
  • sperm protein PH-20
  • PH-20 protein
  • sperm surface antigen 2B1
  • hyaluronidase
  • sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog
  • hyaluronidase, zona pellucida binding
  • sperm adhesion molecule 1
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