SPAM1 Products
(Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1))
Categories
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1\; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
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Featured SPAM1 Categories
SPAM1 Antibodies
High quality antibodies with extensive validation data.
SPAM1 ELISA Kits
Reliable ELISA kits for a wide range of species.
SPAM1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SPAM1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IHC
Validations
- (6)
Cat. No.
ABIN1513554
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN6265252
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (6)
- (1)
Cat. No.
ABIN562973
Quantity
50 μL
Datasheet
Datasheet
Recommended SPAM1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959661
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959662
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6974834
Quantity
96 tests
Datasheet
Datasheet
Recommended SPAM1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321072
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN6964321
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321071
Quantity
25 μg
Datasheet
Datasheet
Latest Publications for our SPAM1 products
: "Hyaluronan synthases and hyaluronidases in nasal polyps." in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, Vol. 273, Issue 7, pp. 1801-8, (2016) (PubMed).: "Expression of a functional recombinant oleosin-human hyaluronidase hPH-20 fusion in Arabidopsis thaliana." in: Protein expression and purification, Vol. 103, pp. 23-7, (2014) (PubMed).
: "Investigation of the mechanisms by which the molecular chaperone HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition." in: Molecular human reproduction, Vol. 19, Issue 3, pp. 120-35, (2013) (PubMed).
: "Autodisplay of catalytically active human hyaluronidase hPH-20 and testing of enzyme inhibitors." in: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Vol. 42, Issue 1-2, pp. 138-47, (2010) (PubMed).
: "Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells." in: American journal of respiratory cell and molecular biology, Vol. 39, Issue 3, pp. 289-95, (2008) (PubMed).
in: (PubMed).
Synonyms and alternative names related to SPAM1
sperm adhesion molecule 1 (Spam1), sperm adhesion molecule 1 (SPAM1), sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog (spam1.L), sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), sperm adhesion molecule 1 (spam1), AV039194, HYA1, HYAL1, HYAL3, HYAL5, im:6902904, Ph-20, PH-20, PH20, SPAG15, Spam, spam1, XEH1, zgc:158668Protein level used designations for SPAM1
- hyal-PH20
- hyaluronidase PH-20
- hyaluronoglucosaminidase PH-20
- sperm surface protein PH-20
- sperm protein PH-20
- PH-20 protein
- sperm surface antigen 2B1
- hyaluronidase
- sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog
- hyaluronidase, zona pellucida binding
- sperm adhesion molecule 1
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