SOS1 Products
(Son of Sevenless Homolog 1 (SOS1))
Categories
This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008].
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Featured SOS1 Categories
SOS1 Antibodies
High quality antibodies with extensive validation data.
SOS1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SOS1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC
Validations
- (4)
Cat. No.
ABIN7170318
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, PLA
Validations
- (4)
Cat. No.
ABIN520376
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IF, EIA
Validations
- (3)
Cat. No.
ABIN238504
Quantity
0.1 mg
Datasheet
Datasheet
Recommended SOS1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970366
Quantity
96 tests
Datasheet
Datasheet
Recommended SOS1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1320973
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3095504
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3135535
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SOS1 products
: "Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes." in: The Journal of biological chemistry, Vol. 283, Issue 5, pp. 2465-9, (2008) (PubMed).: "GEFs in growth factor signaling." in: Growth factors (Chur, Switzerland), Vol. 25, Issue 5, pp. 355-61, (2008) (PubMed).
: "Structural basis of the differential binding of the SH3 domains of Grb2 adaptor to the guanine nucleotide exchange factor Sos1." in: Archives of biochemistry and biophysics, Vol. 479, Issue 1, pp. 52-62, (2008) (PubMed).
: "Effects of SHIP-1 on MMP2 secretion and invasion of SR3Y1 cells." in: Journal of genetics and genomics = Yi chuan xue bao, Vol. 34, Issue 4, pp. 285-93, (2007) (PubMed).
: "T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 27, pp. 11382-7, (2007) (PubMed).
: "Light Chain 3 associates with a Sos1 guanine nucleotide exchange factor: its significance in the Sos1-mediated Rac1 signaling leading to membrane ruffling." in: Oncogene, Vol. 21, Issue 46, pp. 7060-6, (2002) (PubMed).
: "Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-SoS complexes." in: Blood, Vol. 98, Issue 6, pp. 1773-81, (2001) (PubMed).
: "ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5966-75, (2000) (PubMed).
: "Signaling from Ras to Rac and beyond: not just a matter of GEFs." in: The EMBO journal, Vol. 19, Issue 11, pp. 2393-8, (2000) (PubMed).
: "Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor." in: Cell, Vol. 73, Issue 3, pp. 611-20, (1993) (PubMed).
Synonyms and alternative names related to SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1 (SOS1), son of sevenless homolog 1 (Drosophila) (Sos1), SOS Ras/Rac guanine nucleotide exchange factor 1 (Sos1), 4430401P03Rik, 9630010N06, AI449023, GF1, GGF1, GINGF, HGF, NS4Protein level used designations for SOS1
- SOS-1
- gingival fibromatosis, hereditary, 1
- guanine nucleotide exchange factor
- son of sevenless homolog 1
- guanine nucleotide releasing factor
- ras guanine exchange factor
- son-of-sevenless 1
- Son of sevenless homolog 1
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