SMPD3 Products
(Sphingomyelin Phosphodiesterase 3 (SMPD3))
Categories
Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. Overexpression enhances cell death, suggesting that it may be involved in apoptosis control. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF- kappa-B activation under inflammatory conditions.
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Featured SMPD3 Categories
SMPD3 Antibodies
High quality antibodies with extensive validation data.
SMPD3 ELISA Kits
Reliable ELISA kits for a wide range of species.
SMPD3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SMPD3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (2)
- (2)
Cat. No.
ABIN949454
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IP
Validations
- (2)
Cat. No.
ABIN7170557
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB
Validations
- (1)
- (2)
Cat. No.
ABIN2783713
Quantity
100 μL
Datasheet
Datasheet
Recommended SMPD3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970397
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5690953
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN435927
Quantity
96 tests
Datasheet
Datasheet
Recommended SMPD3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1320702
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1320704
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7422046
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our SMPD3 products
: "TSAP6 is a novel candidate marker of poor survival in metastatic high-grade serous carcinoma." in: Human pathology, Vol. 60, pp. 180-187, (2016) (PubMed).: "Dysregulated sphingolipid metabolism in endometriosis." in: The Journal of clinical endocrinology and metabolism, Vol. 99, Issue 10, pp. E1913-21, (2014) (PubMed).
: "Analysis of membrane topology of neutral sphingomyelinase 2." in: FEBS letters, Vol. 581, Issue 7, pp. 1323-8, (2007) (PubMed).
Synonyms and alternative names related to SMPD3
sphingomyelin phosphodiesterase 3 (SMPD3), sphingomyelin phosphodiesterase 3, neutral (Smpd3), sphingomyelin phosphodiesterase 3 (Smpd3), 4631433G07Rik, AI427456, AW537966, cca1, fro, nSMase2, NSMASE2Protein level used designations for SMPD3
- sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
- nSMase-2
- neutral sphingomyelinase 2
- neutral sphingomyelinase II
- sphingomyelin phosphodiesterase 3
- confluent 3Y1 cell-associated 1
- confluent 3Y1 cell-associated protein 1
- nSMase2
- neutral sphingomyelin phosphodiesterase 3
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