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SMG1 Products

(pi-3-Kinase-Related Kinase SMG-1 (SMG1))

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This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013].

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Featured SMG1 Categories

SMG1 Antibodies

High quality antibodies with extensive validation data.

SMG1 ELISA Kits

Reliable ELISA kits for a wide range of species.

Recommended SMG1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB, IHC (p)
Validations
  • (2)
  • (4)
Cat. No. ABIN524936
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IHC (p)
Validations
  • (4)
Cat. No. ABIN524937
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IF
Validations
  • (3)
Cat. No. ABIN564996
Quantity 100 μg
Datasheet Datasheet

Recommended SMG1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1157385
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1157386
Quantity 96 tests
Datasheet Datasheet

Recommended SMG1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1320674
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our SMG1 products

Gubanova, Brown, Ivanov, Helleday, Mills, Yarbrough, Issaeva: "Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 5, pp. 1257-67, (2012) (PubMed).

Arias-Palomo, Yamashita, Fernández, Núñez-Ramírez, Bamba, Izumi, Ohno, Llorca: "The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8." in: Genes & development, Vol. 25, Issue 2, pp. 153-64, (2011) (PubMed).

Usuki, Yamashita, Fujimura: "Post-transcriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure." in: The Journal of biological chemistry, Vol. 286, Issue 8, pp. 6641-9, (2011) (PubMed).

Kaizuka, Hara, Oshiro, Kikkawa, Yonezawa, Takehana, Iemura, Natsume, Mizushima: "Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly." in: The Journal of biological chemistry, Vol. 285, Issue 26, pp. 20109-16, (2010) (PubMed).

McIlwain, Pan, Reilly, Elia, McCracken, Wakeham, Itie-Youten, Blencowe, Mak: "Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 27, pp. 12186-91, (2010) (PubMed).

Stalder, Mühlemann: "Processing bodies are not required for mammalian nonsense-mediated mRNA decay." in: RNA (New York, N.Y.), Vol. 15, Issue 7, pp. 1265-73, (2009) (PubMed).

Kang, Reardon, Kemp, Sancar: "Circadian oscillation of nucleotide excision repair in mammalian brain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 8, pp. 2864-7, (2009) (PubMed).

Brumbaugh, Otterness, Geisen, Oliveira, Brognard, Li, Lejeune, Tibbetts, Maquat, Abraham: "The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells." in: Molecular cell, Vol. 14, Issue 5, pp. 585-98, (2004) (PubMed).

Abraham: "The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways." in: DNA repair, Vol. 3, Issue 8-9, pp. 919-25, (2004) (PubMed).

Cantrell: "Phosphoinositide 3-kinase signalling pathways." in: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, (2001) (PubMed).

Synonyms and alternative names related to SMG1

SMG1, nonsense mediated mRNA decay associated PI3K related kinase (SMG1), SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) (Smg1), SMG1 phosphatidylinositol 3-kinase-related kinase (smg1), Serine/threonine-protein kinase smg-1 (smg-1), 61E3.4, 2610207I05Rik, 5430435M13Rik, ATX, C130002K18Rik, LIP, mKIAA0421, zgc:152973

Protein level used designations for SMG1

  • PI-3-kinase-related kinase SMG-1
  • lambda-interacting protein
  • lambda/iota protein kinase C-interacting protein
  • serine/threonine-protein kinase SMG1
  • smg-1 homolog, phosphatidylinositol 3-kinase-related kinase
  • SMG-1
  • phosphatidylinositol 3-kinase-related protein kinase
  • SMG1 homolog, phosphatidylinositol 3-kinase-related kinase
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