SMCR8 Products
(Smith-Magenis Syndrome Chromosome Region, Candidate 8 (SMCR8))
Categories
Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. {ECO:0000250|UniProtKB:Q8TEV9}.
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Featured SMCR8 Categories
SMCR8 Antibodies
High quality antibodies with extensive validation data.
Recommended SMCR8 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
ELISA
Validations
Cat. No.
ABIN7095499
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
Cat. No.
ABIN7452051
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
Cat. No.
ABIN6753676
Quantity
100 μL
Datasheet
Datasheet
Recommended SMCR8 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3076918
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3122079
Quantity
1 mg
Datasheet
Datasheet
Synonyms and alternative names related to SMCR8
Smith-Magenis syndrome chromosome region, candidate 8 (SMCR8), Smith-Magenis syndrome chromosome region, candidate 8 homolog (human) (Smcr8), Smith-Magenis syndrome chromosome region, candidate 8 (Smcr8), Smith-Magenis syndrome chromosome region, candidate 8b (smcr8b), 2310076G09Rik, AI642055, D030073L15Rik, RGD1564621, smcr8Protein level used designations for SMCR8
- Smith-Magenis syndrome chromosomal region candidate gene 8 protein
- Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog
- Smith-Magenis syndrome chromosome region, candidate 8 homolog
- Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog B
- guanine nucleotide exchange protein smcr8b
- smith-Magenis syndrome chromosomal region candidate gene 8-B protein homolog
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