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SMC5 Products

(Structural Maintenance of Chromosomes 5 (SMC5))

Categories

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression\; the function seems to be independent of SMC6 (By similarity).

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Featured SMC5 Categories

SMC5 Antibodies

High quality antibodies with extensive validation data.

SMC5 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SMC5 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IF, FACS
Validations
  • (2)
Cat. No. ABIN570758
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN1682829
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN7170870
Quantity 100 μg
Datasheet Datasheet

Recommended SMC5 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6210878
Quantity 96 tests
Datasheet Datasheet

Recommended SMC5 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1320663
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3095581
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3136442
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our SMC5 products

Hwang, Sun, OBrien, Eppig, Handel, Jordan: "SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes." in: Development (Cambridge, England), Vol. 144, Issue 9, pp. 1648-1660, (2017) (PubMed).

Franklin, Zhang, Chen, Paulsson, Mitchell-Jordan, Li, Ping, Vondriska: "Specialized compartments of cardiac nuclei exhibit distinct proteomic anatomy." in: Molecular & cellular proteomics : MCP, Vol. 10, Issue 1, pp. M110.000703, (2011) (PubMed).

Draskovic, Arnoult, Steiner, Bacchetti, Lomonte, Londoño-Vallejo: "Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 37, pp. 15726-31, (2009) (PubMed).

Pebernard, Perry, Tainer, Boddy: "Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability." in: Molecular biology of the cell, Vol. 19, Issue 10, pp. 4099-109, (2008) (PubMed).

Synonyms and alternative names related to SMC5

structural maintenance of chromosomes 5 (SMC5), structural maintenance of chromosomes 5 (smc5), structural maintenance of chromosomes 5 (Smc5), structural maintenance of chromosomes 5 S homeolog (smc5.S), F1N13.60, F1N13_60, mKIAA0594, MLZ-453, mSMC5, SMC-5, SMC5L1, Smc5l1, structural maintenance of chromosomes 5

Protein level used designations for SMC5

  • SMC protein 5
  • structural maintenance of chromosomes protein 5
  • SMC-5
  • SMC5 structural maintenance of chromosomes 5-like 1
  • hSMC5
  • protein expressed in male leptotene and zygotene spermatocytes 453
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