SMC1A Products
(Structural Maintenance of Chromosomes 1A (SMC1A))
Categories
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq, Jul 2008].
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Featured SMC1A Categories
SMC1A Antibodies
High quality antibodies with extensive validation data.
SMC1A ELISA Kits
Reliable ELISA kits for a wide range of species.
SMC1A Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SMC1A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP
Validations
- (7)
Cat. No.
ABIN3019554
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, FACS, ICC
Validations
- (1)
- (4)
Cat. No.
ABIN969406
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (4)
Cat. No.
ABIN6255569
Quantity
100 μL
Datasheet
Datasheet
Recommended SMC1A ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380699
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380263
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended SMC1A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1320652
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3095589
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3137039
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SMC1A products
: "ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib." in: Translational oncology, Vol. 10, Issue 2, pp. 190-196, (2017) (PubMed).: "Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation." in: The EMBO journal, Vol. 34, Issue 10, pp. 1399-416, (2015) (PubMed).
: "Comparison of the cytotoxicity of cladribine and clofarabine when combined with fludarabine and busulfan in AML cells: Enhancement of cytotoxicity with epigenetic modulators." in: Experimental hematology, Vol. 43, Issue 6, pp. 448-61.e2, (2015) (PubMed).
: "The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation." in: eLife, Vol. 3, pp. e03297, (2014) (PubMed).
: "Mutant cohesin drives chromosomal instability in early colorectal adenomas." in: Human molecular genetics, Vol. 23, Issue 25, pp. 6773-8, (2014) (PubMed).
: "SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs." in: Nature communications, Vol. 4, pp. 1824, (2013) (PubMed).
: "Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 49, pp. 19920-5, (2013) (PubMed).
: "Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53." in: EMBO molecular medicine, Vol. 4, Issue 6, pp. 515-27, (2012) (PubMed).
: "Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines." in: Experimental hematology, Vol. 40, Issue 10, pp. 800-10, (2012) (PubMed).
: "Loss of ATM kinase activity leads to embryonic lethality in mice." in: The Journal of cell biology, Vol. 198, Issue 3, pp. 295-304, (2012) (PubMed).
Synonyms and alternative names related to SMC1A
structural maintenance of chromosomes 1A (SMC1A), structural maintenance of chromosomes 1A (smc1a), structural maintenance of chromosomes 1A (Smc1a), structural maintenance of chromosomes 1A b (smc1ab), structural maintenance of chromosomes 1A L homeolog (smc1a.L), 5830426I24Rik, CDLS2, DXS423E, mKIAA0178, NV15570, SB1.8, Sb1.8, SMC-1A, SMC1, Smc1, smc1, smc1a, smc1aa, SMC1alpha, Smc1alpha, SMC1L1, Smc1l1, smc1l1, SMCB, Smcb, xSMC1Protein level used designations for SMC1A
- SMC protein 1A
- SMC-1-alpha
- SMC1 (structural maintenance of chromosomes 1, yeast)-like 1
- segregation of mitotic chromosomes 1
- structural maintenance of chromosomes protein 1A
- SMC-protein
- SMC1 structural maintenance of chromosomes 1-like 1
- structural maintenance of chromosomes 1A
- structural maintenance of chromosomes protein 1A-like
- SMC (segregation of mitotic chromosomes 1)-like 1
- chromosome segregation protein SmcB
- segregation of mitotic chromosomes b
- SMC1 protein cohesin subunit
- structural maintenance of chromosomes 1
- DXhXs423e
- SMC-like 1
- segregation of mitotic chromosomes-like 1
- structural maintenance of chromosomes 1 like 1
- 14S cohesin SMC1 subunit
- structural maintenance of chromosomes 1A a
- LOW QUALITY PROTEIN: structural maintenance of chromosomes protein 1A
Did you look for something else?
- SMARCE1
- SMARCD3
- SMARCD2
- SMARCD1
- SMARCC2
- SMARCC1
- SMARCB1
- SMARCAL1
- SMARCAD1
- SMARCA5
- SMARCA4
- SMARCA2
- SMARCA1
- SMAP2
- SMAP1
- Small Ubiquitin Related Modifier Protein 1
- Small Ubiquitin Related Modifier 3
- Small Proline-Rich Protein 2B
- Small Nuclear RNA Activating Complex, Polypeptide 1, 43kDa
- Small Nuclear Ribonucleoprotein Polypeptide A
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