SMARCA4 Products
(SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4))
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The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
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Featured SMARCA4 Categories
SMARCA4 Antibodies
High quality antibodies with extensive validation data.
SMARCA4 ELISA Kits
Reliable ELISA kits for a wide range of species.
SMARCA4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SMARCA4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF, IHC (p), CUT&RUN
Validations
- (2)
- (1)
Cat. No.
ABIN6991990
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IP
Validations
- (5)
Cat. No.
ABIN3022959
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IF, IP
Validations
- (6)
Cat. No.
ABIN2451926
Quantity
100 μg
Datasheet
Datasheet
Recommended SMARCA4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6975082
Quantity
96 tests
Datasheet
Datasheet
Recommended SMARCA4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1320623
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (2)
Cat. No.
ABIN2669726
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2131870
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our SMARCA4 products
: "Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1." in: Molecular metabolism, Vol. 6, Issue 1, pp. 138-147, (2018) (PubMed).: "Brg1 Enables Rapid Growth of the Early Embryo by Suppressing Genes That Regulate Apoptosis and Cell Growth Arrest." in: Molecular and cellular biology, Vol. 36, Issue 15, pp. 1990-2010, (2016) (PubMed).
: "SNORD76, a box C/D snoRNA, acts as a tumor suppressor in glioblastoma." in: Scientific reports, Vol. 5, pp. 8588, (2015) (PubMed).
: "Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 29, Issue 1, pp. 60-6, (2015) (PubMed).
: "Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation." in: Nucleic acids research, Vol. 42, Issue 5, pp. 2958-75, (2014) (PubMed).
: "Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes." in: Genes & development, Vol. 25, Issue 9, pp. 946-58, (2011) (PubMed).
: "Chromatin remodeling by imitation switch (ISWI) class ATP-dependent remodelers is stimulated by histone variant H2A.Z." in: The Journal of biological chemistry, Vol. 285, Issue 7, pp. 4645-51, (2010) (PubMed).
: "Production of a rat monoclonal antibody against Brg1." in: Hybridoma (2005), Vol. 28, Issue 6, pp. 463-6, (2009) (PubMed).
: "The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes." in: The Journal of biological chemistry, Vol. 281, Issue 29, pp. 20233-41, (2006) (PubMed).
Synonyms and alternative names related to SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (Smarca4), b2b692Clo, BAF190, BAF190A, brg-1, BRG1, Brg1, HP1-BP72, hSNF2b, MRD16, RTPS2, SMARCA4, SNF2, SNF2beta, SNF2L4, SNF2LB, SW1/SNF, SWI2Protein level used designations for SMARCA4
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4
- transcription activator BRG1-like
- ATP-dependent helicase SMARCA4
- BRG1-associated factor 190A
- BRM/SWI2-related gene 1
- SNF2-beta
- SNF2-like 4
- brahma protein-like 1
- global transcription activator homologous sequence
- homeotic gene regulator
- mitotic growth and transcription activator
- nuclear protein GRB1
- protein BRG-1
- protein brahma homolog 1
- sucrose nonfermenting-like 4
- transcription activator BRG1
- BAF190A
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- SWI/SNF related transcriptional activator
- WI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Did you look for something else?
- SMARCA2
- SMARCA1
- SMAP2
- SMAP1
- Small Ubiquitin Related Modifier Protein 1
- Small Ubiquitin Related Modifier 3
- Small Proline-Rich Protein 2B
- Small Nuclear RNA Activating Complex, Polypeptide 1, 43kDa
- Small Nuclear Ribonucleoprotein Polypeptide A
- Small Cajal Body-Specific RNA 22
- SMAGP
- SMAD9
- SMAD7
- SMAD6
- SMAD5
- SMAD4
- Smad2/3
- SMAD2
- Smad1/9
- SMAD1/5/8/9
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