SLUG Products
(SLUG)
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Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box- containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity). {ECO:0000250}.
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Recommended SLUG Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p), IF
Validations
- (3)
- (4)
Cat. No.
ABIN6242822
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Rabbit, Rat
Application
WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro)
Validations
- (3)
- (3)
Cat. No.
ABIN685747
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN7226288
Quantity
100 μL
Datasheet
Datasheet
Recommended SLUG Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125118
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our SLUG products
: "SLUG/HIF1-α/miR-221 regulatory circuit in endometrial cancer." in: Gene, Vol. 711, pp. 143938, (2019) (PubMed).: "Immunoexpression of transcription factors in urothelial bladder carcinomas." in: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, Vol. 58, Issue 3, pp. 863-869, (2018) (PubMed).
: "The zinc-finger transcriptional factor Slug transcriptionally downregulates ERα by recruiting lysine-specific demethylase 1 in human breast cancer." in: Oncogenesis, Vol. 6, Issue 5, pp. e330, (2017) (PubMed).
: "Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation." in: Oncogene, Vol. 36, Issue 42, pp. 5885-5896, (2017) (PubMed).
: "RCP induces Slug expression and cancer cell invasion by stabilizing β1 integrin." in: Oncogene, (2016) (PubMed).
: "Overexpression of SDF-1 activates the NF-κB pathway to induce epithelial to mesenchymal transition and cancer stem cell-like phenotypes of breast cancer cells." in: International journal of oncology, Vol. 48, Issue 3, pp. 1085-94, (2016) (PubMed).
: "Overexpression of Livin promotes migration and invasion of colorectal cancer cells by induction of epithelial-mesenchymal transition via NF-κB activation." in: OncoTargets and therapy, Vol. 9, pp. 1011-21, (2016) (PubMed).
: "Maxillary calcifying epithelial odontogenic tumor with sinus and buccal vestibule extension: a case report and immunohistochemical study." in: Diagnostic pathology, Vol. 11, Issue 1, pp. 134, (2016) (PubMed).
: "miR-33a suppresses the nuclear translocation of ?-catenin to enhance gemcitabine sensitivity in human pancreatic cancer cells." in: Tumour biology, (2015) (PubMed).
: "Androgen receptor inhibits epithelial-mesenchymal transition, migration, and invasion of PC-3 prostate cancer cells." in: Cancer letters, Vol. 369, Issue 1, pp. 103-11, (2015) (PubMed).
Synonyms and alternative names related to SLUG
snail family zinc finger 2 (Snai2), snail family transcriptional repressor 2 (SNAI2), Slug, SLUG, Slugh, SLUGH, SLUGH1, Snail2, SNAIL2, WS2DProtein level used designations for SLUG
- Neural crest transcription factor Slug
- Protein snail homolog 2
- neural crest transcription factor Slug
- protein snail homolog 2
- slug, chicken homolog
- snail homolog 2
- zinc finger protein SNAI2
- neural crest transcription factor SLUG
- slug (chicken homolog), zinc finger protein
- snail family zinc finger 2
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