SLC8A1 Products
(Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1))
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In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004].
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SLC8A1 Antibodies
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SLC8A1 ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended SLC8A1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN6148050
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, FACS, IHC (p)
Validations
- (3)
Cat. No.
ABIN652886
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (3)
Cat. No.
ABIN7043754
Quantity
25 μL
Datasheet
Datasheet
Recommended SLC8A1 ELISA Kits
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Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
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Cat. No.
ABIN6970358
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5595099
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
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Validations
Cat. No.
ABIN809058
Quantity
96 tests
Datasheet
Datasheet
Latest Publications for our SLC8A1 products
: "Effectiveness of gene delivery systems for pluripotent and differentiated cells." in: Molecular therapy. Methods & clinical development, Vol. 2, pp. 14067, (2015) (PubMed).: "Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure." in: Nature communications, Vol. 6, pp. 7229, (2015) (PubMed).
: "Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes." in: Journal of molecular and cellular cardiology, Vol. 52, Issue 5, pp. 988-97, (2012) (PubMed).
: "Inverse correlation between the extent of N-glycan branching and intercellular adhesion in epithelia. Contribution of the Na,K-ATPase beta1 subunit." in: The Journal of biological chemistry, Vol. 283, Issue 4, pp. 2192-202, (2008) (PubMed).
: "Na+/Ca2+ exchange inhibition protects the rat heart from ischemia-reperfusion injury by blocking energy-wasting processes." in: American journal of physiology. Heart and circulatory physiology, Vol. 288, Issue 4, pp. H1699-707, (2005) (PubMed).
: "Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity." in: Cell, Vol. 120, Issue 2, pp. 275-85, (2005) (PubMed).
: "Neurodegeneration: cellular defences destroyed." in: Nature, Vol. 433, Issue 7027, pp. 696-8, (2005) (PubMed).
: "Dietary calcium deficiency increases Ca2+ uptake and Ca2+ extrusion mechanisms in chick enterocytes." in: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, Vol. 139, Issue 2, pp. 133-41, (2004) (PubMed).
: "Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handling." in: Circulation research, Vol. 92, Issue 5, pp. e52-9, (2003) (PubMed).
: "Regulation of phosphatidylinositol-4,5-biphosphate bound to the bovine cardiac Na+/Ca2+ exchanger." in: Annals of the New York Academy of Sciences, Vol. 976, pp. 288-99, (2002) (PubMed).
Synonyms and alternative names related to SLC8A1
solute carrier family 8 member A1 (SLC8A1), solute carrier family 8 (sodium/calcium exchanger), member 1 (Slc8a1), solute carrier family 8 member A1 (Slc8a1), solute carrier family 8 (sodium/calcium exchanger), member 1b (slc8a1b), sodium/calcium exchanger 1 (Tsp_07038), AI852629, AV344025, D930008O12Rik, Ncx, NCX1, Ncx1, ncx1n, SLC8A1Protein level used designations for SLC8A1
- Na(+)/Ca(2+)-exchange protein 1
- Na+/Ca++ exchanger
- Na+/Ca2+ exchanger
- sodium/calcium exchanger 1
- Na/Ca exchanger
- sodium/calcium exchanger isoform NaCa7
- Na-Ca exchanger
- solute carrier family 8, member 1
- sodium-calcium exchanger
- solute carrier family 8 (sodium/calcium exchanger), member 1
- ncx1b
- sodium calcium exchanger 1n
- sodium/calcium exchanger
- sodium/calcium exchanger 1-like
- sodium/calcium exchanger isoform NaCa13
- sodium/calcium exchanger isoform NaCa3
- sodium/calcium exchanger isoform NaCa9
- solute carrier family 8 member 1
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