SLC7A5 Products
(Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 5 (SLC7A5))
Categories
Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood- brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L- leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts.
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Featured SLC7A5 Categories
SLC7A5 Antibodies
High quality antibodies with extensive validation data.
SLC7A5 ELISA Kits
Reliable ELISA kits for a wide range of species.
SLC7A5 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SLC7A5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Pig, Rat
Application
WB, ELISA, IHC (p), IF (cc)
Validations
- (2)
- (3)
Cat. No.
ABIN1387470
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (3)
Cat. No.
ABIN1682793
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN6243100
Quantity
200 μL
Datasheet
Datasheet
Recommended SLC7A5 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6959624
Quantity
96 tests
Datasheet
Datasheet
Recommended SLC7A5 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3114267
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3137587
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN6381061
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SLC7A5 products
: "Significant relationship between the LAT1 expression pattern and chemoresistance in ovarian clear cell carcinoma." in: Virchows Archiv : an international journal of pathology, (2019) (PubMed).: "Possible Molecular Mechanisms by Which an Essential Oil Blend from Star Anise, Rosemary, Thyme, and Oregano and Saponins Increase the Performance and Ileal Protein Digestibility of Growing Broilers." in: Journal of agricultural and food chemistry, Vol. 65, Issue 32, pp. 6821-6830, (2017) (PubMed).
: "Leucine reduces reactive oxygen species levels via an energy metabolism switch by activation of the mTOR-HIF-1α pathway in porcine intestinal epithelial cells." in: The international journal of biochemistry & cell biology, Vol. 89, pp. 42-56, (2017) (PubMed).
: "Anabolic sensitivity of postprandial muscle protein synthesis to the ingestion of a protein-dense food is reduced in overweight and obese young adults." in: The American journal of clinical nutrition, Vol. 104, Issue 4, pp. 1014-1022, (2016) (PubMed).
: "Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers." in: Science (New York, N.Y.), Vol. 353, Issue 6304, pp. 1161-5, (2016) (PubMed).
: "High expression of CD98 alters epithelial barrier functions to promote induction of airway allergy." in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Vol. 42, Issue 7, pp. 1051-9, (2012) (PubMed).
: "Production and characterization of highly tumor-specific rat monoclonal antibodies recognizing the extracellular domain of human L-type amino-acid transporter 1." in: Cancer science, Vol. 99, Issue 5, pp. 1000-7, (2008) (PubMed).
: "Transcriptional regulation of the LAT-1/CD98 light chain." in: Biochemical and biophysical research communications, Vol. 318, Issue 2, pp. 529-34, (2004) (PubMed).
: "Expression of a system L neutral amino acid transporter at the blood-brain barrier." in: Neuroreport, Vol. 11, Issue 16, pp. 3507-11, (2001) (PubMed).
: "Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines." in: Biochimica et biophysica acta, Vol. 1514, Issue 2, pp. 291-302, (2001) (PubMed).
Synonyms and alternative names related to SLC7A5
solute carrier family 7 member 5 (SLC7A5), solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 (Slc7a5), solute carrier family 7 (amino acid transporter light chain, L system), member 5 (SLC7A5), solute carrier family 7 member 5 (Slc7a5), solute carrier family 7 member 5 S homeolog (slc7a5.S), solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 (Slc3a2), 4F2, 4F2HC, 4F2LC, AI314110, CD98, Cd98, D0H16S474E, D16S469E, E16, hLAT1, JHI-21, LAT-1, LAT1, Ly-10, Ly-m10, Ly10, Mdu1, Mgp-2hc, MPE16, NACAE, SLC7A5, slc7a5a, TA1Protein level used designations for SLC7A5
- 4F2 LC
- 4F2 light chain
- CD98 light chain
- L-type amino acid transporter 1
- integral membrane protein E16
- large neutral amino acids transporter 1
- large neutral amino acids transporter small subunit 1
- sodium-independent neutral amino acid transporter LAT1
- solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
- solute carrier family 7 member 5
- y+ system cationic amino acid transporter
- 4F2LC
- LAT1 light chain
- blood-brain barrier large neutral amino acid transporter light chain
- tumor-associated protein 1
- L amino acid transporter-1
- solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 a
- large neutral amino acids transporter small subunit 1-like
- 4F2 cell-surface antigen heavy chain
- CD98 antigen
- CD98 heavy chain
- antigen identified by monoclonal antibodies 4F2
- type II transmembrane protein
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