Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

SLC22A1 Products

(Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1))
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008].

antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Featured SLC22A1 Categories

SLC22A1 Antibodies

High quality antibodies with extensive validation data.

SLC22A1 ELISA Kits

Reliable ELISA kits for a wide range of species.

SLC22A1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SLC22A1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, FACS
Validations
  • (3)
  • (2)
Cat. No. ABIN969400
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF
Validations
  • (3)
Cat. No. ABIN7075663
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7170131
Quantity 100 μg
Datasheet Datasheet

Recommended SLC22A1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative DNA-Binding ELISA
Validations
Cat. No. ABIN5648541
Quantity 96 tests
Datasheet Datasheet

Recommended SLC22A1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7423393
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3109816
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3131351
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our SLC22A1 products

Sekhar, Georgian, Sanderson, Vizcay-Barrena, Brown, Muresan, Fleck, Thomas: "Organic cation transporter 1 (OCT1) is involved in pentamidine transport at the human and mouse blood-brain barrier (BBB)." in: PLoS ONE, Vol. 12, Issue 3, pp. e0173474, (2017) (PubMed).

Zhang, Boxberger, Hagenbuch: "Organic anion transporting polypeptide 1B3 can form homo- and hetero-oligomers." in: PLoS ONE, Vol. 12, Issue 6, pp. e0180257, (2017) (PubMed).

Kim, Raffler, Lu, Lee, Abbey, Saleheen, Rabinowitz, Bennett, Hand, Brown, Rader: "Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport." in: American journal of human genetics, Vol. 101, Issue 4, pp. 489-502, (2017) (PubMed).

Andreev, Brosseau, Carmona, Mes-Masson, Ramotar: "The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicin." in: Scientific reports, Vol. 6, pp. 20508, (2016) (PubMed).

Seitz, Stalmann, Dalila, Chen, Pojar, Dos Santos Pereira, Krätzner, Brockmöller, Tzvetkov: "Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1." in: Genome medicine, Vol. 7, Issue 1, pp. 56, (2015) (PubMed).

Salomon, Muchitsch, Gausterer, Schwagerus, Huwer, Daum, Lehr, Ehrhardt: "The cell line NCl-H441 is a useful in vitro model for transport studies of human distal lung epithelial barrier." in: Molecular pharmaceutics, Vol. 11, Issue 3, pp. 995-1006, (2014) (PubMed).

Boxberger, Hagenbuch, Lampe: "Common drugs inhibit human organic cation transporter 1 (OCT1)-mediated neurotransmitter uptake." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 42, Issue 6, pp. 990-5, (2014) (PubMed).

Zach, Krieger, Foedermayr, Zellhofer, Lutz: "OCT1 (SLC22A1) R61C polymorphism and response to imatinib treatment in chronic myeloid leukemia patients." in: Leukemia & lymphoma, Vol. 49, Issue 11, pp. 2222-3, (2008) (PubMed).

Hirayama, Watanabe, Nakashima, Nanbu, Hamada, Kuniyasu, Nakayama, Kawaguchi, Saito: "Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib-resistance in K562 cells." in: Pharmaceutical research, Vol. 25, Issue 4, pp. 827-35, (2008) (PubMed).

Giannoudis, Davies, Lucas, Harris, Pirmohamed, Clark: "Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia." in: Blood, Vol. 112, Issue 8, pp. 3348-54, (2008) (PubMed).

Synonyms and alternative names related to SLC22A1

solute carrier family 22 member 1 (SLC22A1), solute carrier family 22 (organic cation transporter), member 1 (Slc22a1), solute carrier family 22 member 1 (Slc22a1), solute carrier family 22 member 2-like (LOC421584), HOCT1, Lx1, OCT1, Oct1, oct1_cds, Orct, Orct1, Roct1, SLC22A1, SLC22A2

Protein level used designations for SLC22A1

  • solute carrier family 22 member 1
  • solute carrier family 22 (organic cation transporter), member 1
  • solute carrier family 22 member 1-like
  • pOCT1
  • organic cation transporter 1
  • mOCT1
  • solute carrier family 22, member 1
  • solute carrier family 22 (organic cation transporter), member 2
You are here:
Support