SLC12A6 Products
(Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6))
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This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008].
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Featured SLC12A6 Categories
SLC12A6 Antibodies
High quality antibodies with extensive validation data.
SLC12A6 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SLC12A6 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN656316
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN238578
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (4)
- (1)
Cat. No.
ABIN564298
Quantity
50 μL
Datasheet
Datasheet
Recommended SLC12A6 Proteins
Product
Reactivity
Source
Validations
Cat. No.
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Datasheet
Reactivity
Human
Source
Wheat germ
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Cat. No.
ABIN1320131
Quantity
10 μg
Datasheet
Datasheet
Reactivity
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Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7394462
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3118929
Quantity
1 mg
Datasheet
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Latest Publications for our SLC12A6 products
: "The K-Cl cotransporter KCC3 as an independent prognostic factor in human esophageal squamous cell carcinoma." in: BioMed research international, Vol. 2014, pp. 936401, (2014) (PubMed).: "Potassium-chloride cotransporter 3 interacts with Vav2 to synchronize the cell volume decrease response with cell protrusion dynamics." in: PLoS ONE, Vol. 8, Issue 5, pp. e65294, (2013) (PubMed).
: "Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with ..." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 11, pp. 3865-76, (2012) (PubMed).
: "Transit defect of potassium-chloride Co-transporter 3 is a major pathogenic mechanism in hereditary motor and sensory neuropathy with agenesis of the corpus callosum." in: The Journal of biological chemistry, Vol. 286, Issue 32, pp. 28456-65, (2011) (PubMed).
: "HMSN/ACC truncation mutations disrupt brain-type creatine kinase-dependant activation of K+/Cl- co-transporter 3." in: Human molecular genetics, Vol. 17, Issue 17, pp. 2703-11, (2008) (PubMed).
: "Homooligomeric and heterooligomeric associations between K+-Cl- cotransporter isoforms and between K+-Cl- and Na+-K+-Cl- cotransporters." in: The Journal of biological chemistry, Vol. 282, Issue 25, pp. 18083-93, (2007) (PubMed).
Synonyms and alternative names related to SLC12A6
solute carrier family 12, member 6 (Slc12a6), solute carrier family 12 member 6 (SLC12A6), 9530023I19Rik, ACCPN, gaxp, Kcc3, KCC3, KCC3A, KCC3BProtein level used designations for SLC12A6
- solute carrier family 12 member 6
- furosemide-sensitive KCl cotransporter 3
- K-Cl cotransporter 3
- electroneutral potassium-chloride cotransporter 3
- potassium chloride cotransporter 3
- potassium chloride cotransporter KCC3a-S3
- potassium-chloride transporter-3a
- potassium-chloride transporter-3b
- solute carrier family 12 (potassium/chloride transporters), member 6
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