SLC12A1 Products
(Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1))
Categories
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010].
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Featured SLC12A1 Categories
SLC12A1 Antibodies
High quality antibodies with extensive validation data.
SLC12A1 ELISA Kits
Reliable ELISA kits for a wide range of species.
SLC12A1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SLC12A1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application
WB, IHC
Validations
- (3)
- (5)
Cat. No.
ABIN2776780
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (3)
Cat. No.
ABIN7131078
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC
Validations
- (4)
- (2)
Cat. No.
ABIN863200
Quantity
100 μg
Datasheet
Datasheet
Recommended SLC12A1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970295
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959560
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN579532
Quantity
96 tests
Datasheet
Datasheet
Recommended SLC12A1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1320125
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1320127
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3114728
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SLC12A1 products
: "Collecting Duct Nitric Oxide Synthase 1ß Activation Maintains Sodium Homeostasis During High Sodium Intake Through Suppression of Aldosterone and Renal Angiotensin II Pathways." in: Journal of the American Heart Association, Vol. 6, Issue 10, (2018) (PubMed).: "Identification of the dopamine transporter SLC6A3 as a biomarker for patients with renal cell carcinoma." in: Molecular cancer, Vol. 15, pp. 10, (2016) (PubMed).
: "Polyuria-associated hydronephrosis induced by xenobiotic chemical exposure in mice." in: American journal of physiology. Renal physiology, Vol. 311, Issue 4, pp. F752-F762, (2016) (PubMed).
: "Prostaglandin-E2 Mediated Increase in Calcium and Phosphate Excretion in a Mouse Model of Distal Nephron Salt Wasting." in: PLoS ONE, Vol. 11, Issue 7, pp. e0159804, (2016) (PubMed).
: "Regulation of the Na(+) -K(+) -2Cl(-) cotransporter by cGMP/cGMP-dependent protein kinase I after furosemide administration." in: The FEBS journal, (2015) (PubMed).
: "Inhibition of Mitochondrial Complex-1 Prevents the Downregulation of NKCC2 and ENaCα in Obstructive Kidney Disease." in: Scientific reports, Vol. 5, pp. 12480, (2015) (PubMed).
: "Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK." in: American journal of physiology. Renal physiology, Vol. 307, Issue 1, pp. F96-F106, (2014) (PubMed).
: "Expression of heme oxygenase-1 in thick ascending loop of henle attenuates angiotensin II-dependent hypertension." in: Journal of the American Society of Nephrology : JASN, Vol. 23, Issue 5, pp. 834-41, (2012) (PubMed).
: "Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria." in: Journal of the American Society of Nephrology : JASN, Vol. 23, Issue 11, pp. 1879-90, (2012) (PubMed).
: "Heme oxygenase attenuates angiotensin II-mediated superoxide production in cultured mouse thick ascending loop of Henle cells." in: American journal of physiology. Renal physiology, Vol. 295, Issue 4, pp. F1158-65, (2008) (PubMed).
Synonyms and alternative names related to SLC12A1
si:ch211-220f12.1 (si:ch211-220f12.1), solute carrier family 12 member 1 (SLC12A1), solute carrier family 12 member 1 (Slc12a1), solute carrier family 12, member 1 (Slc12a1), AI788571, BSC1, D630042G03Rik, DKFZp469A2020, mBSC1, NKCC2, Nkcc2, slc12a1, SLC12A1, urehr3Protein level used designations for SLC12A1
- FERM domain-containing protein 4A
- Na/K/Cl cotransporter
- solute carrier family 12 (sodium/potassium/chloride transporters), member 1
- solute carrier family 12 member 1-like
- NKCC2A variant A
- Na-K-2Cl cotransporter
- bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
- kidney-specific Na-K-Cl symporter
- solute carrier family 12 member 1
- Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter)
- Solute carrier family 12, member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter)
- apical Na(2Cl)K cotransporter
- solute carrier family 12, member 1
- BSC1
- bumetanide-sensitive cotransporter type 1
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