SIRT6 Products
(Sirtuin 6 (SIRT6))
Categories
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010].
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Featured SIRT6 Categories
SIRT6 Antibodies
High quality antibodies with extensive validation data.
SIRT6 ELISA Kits
Reliable ELISA kits for a wide range of species.
SIRT6 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SIRT6 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7437191
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, ICC, FACS
Validations
- (5)
Cat. No.
ABIN5542442
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Monkey, Mouse, Rat
Application
WB, IP, IF
Validations
- (3)
Cat. No.
ABIN6241508
Quantity
100 μL
Datasheet
Datasheet
Recommended SIRT6 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959496
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959497
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN5593053
Quantity
96 tests
Datasheet
Datasheet
Recommended SIRT6 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1320053
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125110
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1320054
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our SIRT6 products
: "Protective effects of SIRT6 against lipopolysaccharide (LPS) are mediated by deacetylation of Ku70." in: Molecular immunology, Vol. 101, pp. 312-318, (2019) (PubMed).: "SIRT6 Depletion Sensitizes Human Hepatoma Cells to Chemotherapeutics by Downregulating MDR1 Expression." in: Frontiers in pharmacology, Vol. 9, pp. 194, (2018) (PubMed).
: "SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability." in: Nature communications, Vol. 7, pp. 12235, (2018) (PubMed).
: "Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer." in: The Journal of international medical research, Vol. 46, Issue 4, pp. 1517-1527, (2018) (PubMed).
: "Deacetylation of Ku70 by SIRT6 attenuates Bax-mediated apoptosis in hepatocellular carcinoma." in: Biochemical and biophysical research communications, Vol. 485, Issue 4, pp. 713-719, (2017) (PubMed).
: "SIRT6 Overexpression Potentiates Apoptosis Evasion in Hepatocellular Carcinoma via BCL2-Associated X Protein-Dependent Apoptotic Pathway." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 22, Issue 13, pp. 3372-82, (2016) (PubMed).
: "Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin." in: Scientific reports, Vol. 5, pp. 12012, (2015) (PubMed).
: "SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer." in: Journal of surgical oncology, Vol. 112, Issue 2, pp. 231-7, (2015) (PubMed).
: "Epigenetic modulation of chronic anxiety and pain by histone deacetylation." in: Molecular psychiatry, Vol. 20, Issue 10, pp. 1219-31, (2015) (PubMed).
: "Biochemical characterization of sirtuin 6 in the brain and its involvement in oxidative stress response." in: Neurochemical research, Vol. 40, Issue 1, pp. 59-69, (2015) (PubMed).
Synonyms and alternative names related to SIRT6
sirtuin 6 (Sirt6), sirtuin 6 (SIRT6), sirtuin 6 S homeolog (sirt6.S), sirtuin 6 (sirt6), 2810449N18Rik, AI043036, Sir2l6, SIR2L6, zgc:86729Protein level used designations for SIRT6
- NAD-dependent deacetylase sirtuin-6
- NAD-dependent protein deacetylase sirtuin-6
- SIR2-like protein 6
- regulatory protein SIR2 homolog 6
- sir2-related protein type 6
- sirtuin type 6
- sirtuin (silent mating type information regulation 2 homolog) 6
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