SIRPA Products
(Signal-Regulatory Protein alpha (SIRPA))
Categories
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008].
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Featured SIRPA Categories
SIRPA Antibodies
High quality antibodies with extensive validation data.
SIRPA ELISA Kits
Reliable ELISA kits for a wide range of species.
SIRPA Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SIRPA Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
FACS, ELISA
Validations
- (1)
- (4)
Cat. No.
ABIN5611267
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (5)
Cat. No.
ABIN530824
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (4)
Cat. No.
ABIN6147780
Quantity
100 μL
Datasheet
Datasheet
Recommended SIRPA ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970225
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962326
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959481
Quantity
96 tests
Datasheet
Datasheet
Recommended SIRPA Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (8)
Cat. No.
ABIN7275652
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7275650
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7275654
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our SIRPA products
: "Novel SIRPα Antibodies That Induce Single-Agent Phagocytosis of Tumor Cells while Preserving T Cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 206, Issue 4, pp. 712-721, (2021) (PubMed).: "Luteolin promotes macrophage-mediated phagocytosis by inhibiting CD47 pyroglutamation." in: Translational oncology, Vol. 14, Issue 8, pp. 101129, (2021) (PubMed).
: "The SIRPα-CD47 immune checkpoint in NK cells." in: The Journal of experimental medicine, Vol. 218, Issue 3, (2021) (PubMed).
: "Tumor-selective blockade of CD47 signaling with a CD47/PD-L1 bispecific antibody for enhanced anti-tumor activity and limited toxicity." in: Cancer immunology, immunotherapy : CII, (2020) (PubMed).
: "TRIM2, a novel member of the antiviral family, limits New World arenavirus entry." in: PLoS biology, Vol. 17, Issue 2, pp. e3000137, (2019) (PubMed).
: "A novel fully human anti-CD47 antibody as a potential therapy for human neoplasms with good safety." in: Biochimie, Vol. 151, pp. 54-66, (2018) (PubMed).
: "Cleavage of Signal Regulatory Protein α (SIRPα) Enhances Inflammatory Signaling." in: The Journal of biological chemistry, Vol. 290, Issue 52, pp. 31113-25, (2015) (PubMed).
: "Signal regulatory protein-α protects against cardiac hypertrophy via the disruption of toll-like receptor 4 signaling." in: Hypertension (Dallas, Tex. : 1979), Vol. 63, Issue 1, pp. 96-104, (2013) (PubMed).
: "Enhanced secretion of interferon-gamma by bovine gammadelta T cells induced by coculture with Mycobacterium bovis-infected dendritic cells: evidence for reciprocal activating signals." in: Immunology, Vol. 126, Issue 2, pp. 201-8, (2009) (PubMed).
: "Signal regulatory protein alpha (SIRPalpha) cells in the adaptive response to ESAT-6/CFP-10 protein of tuberculous mycobacteria." in: PLoS ONE, Vol. 4, Issue 7, pp. e6414, (2009) (PubMed).
Synonyms and alternative names related to SIRPA
signal regulatory protein alpha (SIRPA), myeloperoxidase (MPO), signal-regulatory protein alpha (SIRPA), tyrosine-protein phosphatase non-receptor type substrate 1 (LOC458039), tyrosine-protein phosphatase non-receptor type substrate 1 (LOC100400378), tyrosine-protein phosphatase non-receptor type substrate 1 (LOC100590224), signal-regulatory protein alpha (Sirpa), AI835480, BIT, Bit, CD172A, CD172a, MFR, MYD-1, P84, PTPNS1, Ptpns1, SHP-1, SHPS-1, SHPS1, SIRP, SIRP-A1, SIRP-B1, SIRPA, swc3Protein level used designations for SIRPA
- CD172 antigen-like family member A
- brain-immunoglobulin-like molecule with tyrosine-based activation motifs
- inhibitory receptor SHPS-1
- macrophage fusion receptor
- myd-1 antigen
- tyrosine phosphatase SHP substrate 1
- tyrosine-protein phosphatase non-receptor type substrate 1
- MyD-1 antigen
- SHP substrate 1
- SHPS-1
- protein tyrosine phosphatase, non-receptor type substrate 1
- signal-regulatory protein alpha-1
- sirp-alpha-1
- signal-regulatory protein alpha
- signal regulatory protein alpha
- tyrosine-protein phosphatase non-receptor type substrate 1-like
- brain Ig-like molecule with tyrosine-based activation motifs
- brain immunological-like with tyrosine-based motifs
- mSIRP-alpha1
- myD-1 antigen
- Brain immunoglobulin like protein with tyrosine - based activation motifs
- Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1)
- Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1)
- macrophage membrane protein MFP150
- swine workshop cluster 3 antigen
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