SIP1 Products
(Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))
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This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011].
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SIP1 Antibodies
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SIP1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SIP1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, ICC, IHC (p)
Validations
- (4)
Cat. No.
ABIN625932
Quantity
0.05 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IP
Validations
- (3)
Cat. No.
ABIN7153753
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN521936
Quantity
50 μg
Datasheet
Datasheet
Recommended SIP1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6231037
Quantity
96 tests
Datasheet
Datasheet
Recommended SIP1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1320025
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3080724
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3128349
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SIP1 products
: "ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing Sarcoma." in: Genes & cancer, Vol. 4, Issue 11-12, pp. 486-500, (2014) (PubMed).: "JARID2 is involved in transforming growth factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines." in: PLoS ONE, Vol. 9, Issue 12, pp. e115684, (2014) (PubMed).
: "A novel function for the survival motoneuron protein as a translational regulator." in: Human molecular genetics, Vol. 22, Issue 4, pp. 668-84, (2013) (PubMed).
: "Proteomic assessment of a cell model of spinal muscular atrophy." in: BMC neuroscience, Vol. 12, pp. 25, (2011) (PubMed).
: "GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination." in: Nucleic acids research, Vol. 38, Issue 15, pp. 5059-74, (2010) (PubMed).
: "Novel monoclonal antibodies detect Smad-interacting protein 1 (SIP1) in the cytoplasm of human cells from multiple tumor tissue arrays." in: Experimental and molecular pathology, Vol. 89, Issue 2, pp. 182-9, (2010) (PubMed).
: "Regulation of SMN protein stability." in: Molecular and cellular biology, Vol. 29, Issue 5, pp. 1107-15, (2009) (PubMed).
: "SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain." in: Human molecular genetics, Vol. 17, Issue 21, pp. 3399-410, (2008) (PubMed).
: "A novel cell response triggered by interphase centromere structural instability." in: The Journal of cell biology, Vol. 177, Issue 5, pp. 757-68, (2007) (PubMed).
: "Distinct domains of the spinal muscular atrophy protein SMN are required for targeting to Cajal bodies in mammalian cells." in: Journal of cell science, Vol. 119, Issue Pt 4, pp. 680-92, (2006) (PubMed).
Synonyms and alternative names related to SIP1
gem nuclear organelle associated protein 2 (GEMIN2), gem nuclear organelle associated protein 2 (Gemin2), gem (nuclear organelle) associated protein 2 (Gemin2), gem nuclear organelle associated protein 2 S homeolog (gemin2.S), gem (nuclear organelle) associated protein 2 (gemin2), 1700012N19Rik, SIP1, Sip1, sip1, SIP1-delta, sip1-delta, wu:fc52a05, zgc:110274Protein level used designations for SIP1
- SMN interacting protein 1-delta
- component of gems 2
- gem-associated protein 2
- gemin-2
- survival of motor neuron protein interacting protein 1
- SMN-interacting protein 1
- survival of motor neuron protein-interacting protein 1
- survivor of motor neuron protein interacting protein 1
- SMN interacting protein-1
- Survival of motor neuron protein-interacting protein 1
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