Siglece Products
(Sialic Acid Binding Ig-Like Lectin E (Siglece))
Categories
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
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Featured Siglece Categories
Siglece Antibodies
High quality antibodies with extensive validation data.
Recommended Siglece Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
FACS, IP
Validations
- (1)
Cat. No.
ABIN1818480
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Application
FACS, IP
Validations
Cat. No.
ABIN1818481
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Mouse
Application
IHC, WB
Validations
Cat. No.
ABIN1982837
Quantity
50 μg
Datasheet
Datasheet
Recommended Siglece ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730779
Quantity
96 tests
Datasheet
Datasheet
Recommended Siglece Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
Human Cells
Validations
- (1)
Cat. No.
ABIN7320926
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our Siglece products
: "MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 120, Issue 11, pp. e2215376120, (2023) (PubMed).: "Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes." in: Scientific reports, Vol. 7, pp. 45319, (2017) (PubMed).
: "Siglec-E Negatively Regulates the Activation of TLR4 by Controlling Its Endocytosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 8, pp. 3336-3347, (2016) (PubMed).
: "Siglec-E is up-regulated and phosphorylated following lipopolysaccharide stimulation in order to limit TLR-driven cytokine production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 12, pp. 7703-9, (2009) (PubMed).
Synonyms and alternative names related to Siglece
sialic acid binding Ig-like lectin E (Siglece), Cd170, mSiglec-E, Siglec5, Siglec9, Siglec12, Siglecl1Protein level used designations for Siglece
- MIS
- SIGLEC-like 1
- myeloid inhibitory siglec
- sialic acid binding Ig-like lectin 5
- sialic acid-binding Ig-like lectin 12
- sialic acid-binding Ig-like lectin 5
- sialic acid-binding Ig-like lectin E
- sialic acid-binding Ig-like lectin-like 1
- sialic acid-binding immunoglobulin-like lectin E
- siglec-12
- siglec-5
- siglec-E
- siglec-L1
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