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SIGLEC8 Products

(Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM\\\\; MIM 603492) that mediates an association with SLAM-associated protein (SAP\\\\; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010].

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Featured SIGLEC8 Categories

SIGLEC8 Antibodies

High quality antibodies with extensive validation data.

SIGLEC8 ELISA Kits

Reliable ELISA kits for a wide range of species.

SIGLEC8 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SIGLEC8 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN565353
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN525889
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN7186224
Quantity 100 μg
Datasheet Datasheet

Recommended SIGLEC8 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970205
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962264
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959465
Quantity 96 tests
Datasheet Datasheet

Recommended SIGLEC8 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7275591
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1320000
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7275601
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our SIGLEC8 products

Arakawa, Suzukawa, Ohshima, Tashimo, Asari, Matsui, Kobayashi, Shoji, Nagase, Ohta: "Expression of Siglec-8 is regulated by interleukin-5, and serum levels of soluble Siglec-8 may predict responsiveness of severe eosinophilic asthma to mepolizumab." in: Allergology international : official journal of the Japanese Society of Allergology, Vol. 67S, pp. S41-S44, (2019) (PubMed).

Youngblood, Brock, Leung, Falahati, Bochner, Rasmussen, Peterson, Bebbington, Tomasevic: "Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis." in: JCI insight, Vol. 4, Issue 19, (2019) (PubMed).

Yokoi, Choi, Hubbard, Lee, Canning, Lee, Ryu, von Gunten, Bickel, Hudson, Macglashan, Bochner: "Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement." in: The Journal of allergy and clinical immunology, Vol. 121, Issue 2, pp. 499-505.e1, (2008) (PubMed).

von Gunten, Vogel, Schaub, Stadler, Miescher, Crocker, Simon: "Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies." in: The Journal of allergy and clinical immunology, Vol. 119, Issue 4, pp. 1005-11, (2007) (PubMed).

Nutku, Aizawa, Hudson, Bochner: "Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis." in: Blood, Vol. 101, Issue 12, pp. 5014-20, (2003) (PubMed).

Foussias, Yousef, Diamandis: "Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene." in: Biochemical and biophysical research communications, Vol. 278, Issue 3, pp. 775-81, (2000) (PubMed).

Floyd, Ni, Cornish, Zeng, Liu, Carter, Steel, Crocker: "Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily." in: The Journal of biological chemistry, Vol. 275, Issue 2, pp. 861-6, (2000) (PubMed).

Kikly, Bochner, Freeman, Tan, Gallagher, Dalessio, Holmes, Abrahamson, Erickson-Miller, Murdock, Tachimoto, Schleimer, White: "Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils." in: The Journal of allergy and clinical immunology, Vol. 105, Issue 6 Pt 1, pp. 1093-100, (2000) (PubMed).

Synonyms and alternative names related to SIGLEC8

sialic acid binding Ig like lectin 8 (SIGLEC8), sialic acid-binding Ig-like lectin 8 (LOC506364), SAF2, SIGLEC-8, SIGLEC8, SIGLEC8L

Protein level used designations for SIGLEC8

  • CDw329
  • SAF-2
  • sialic acid-binding Ig-like lectin 8
  • sialoadhesin family member 2
  • sialic acid binding Ig-like lectin 8
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