SIGLEC7 Products
(Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
Categories
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
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Featured SIGLEC7 Categories
SIGLEC7 Antibodies
High quality antibodies with extensive validation data.
SIGLEC7 ELISA Kits
Reliable ELISA kits for a wide range of species.
SIGLEC7 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SIGLEC7 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
Cat. No.
ABIN7169566
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7438064
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
Cat. No.
ABIN388428
Quantity
400 μL
Datasheet
Datasheet
Recommended SIGLEC7 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (5)
Cat. No.
ABIN6574286
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN5510679
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4884544
Quantity
96 tests
Datasheet
Datasheet
Recommended SIGLEC7 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7092801
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319997
Quantity
2 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319998
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our SIGLEC7 products
: "Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes." in: Scientific reports, Vol. 7, pp. 45319, (2017) (PubMed).: "Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides." in: PLoS biology, Vol. 10, Issue 12, pp. e1001448, (2012) (PubMed).
: "Engagement of Siglec-7 receptor induces a pro-inflammatory response selectively in monocytes." in: PLoS ONE, Vol. 7, Issue 9, pp. e45821, (2012) (PubMed).
: "Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids." in: PLoS ONE, Vol. 6, Issue 9, pp. e24559, (2011) (PubMed).
: "Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates." in: Cellular immunology, Vol. 250, Issue 1-2, pp. 91-104, (2008) (PubMed).
: "Sialic acid-binding immunoglobulin-like lectin 7 mediates selective recognition of sialylated glycans expressed on Campylobacter jejuni lipooligosaccharides." in: Infection and immunity, Vol. 74, Issue 7, pp. 4133-41, (2006) (PubMed).
: "High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family." in: The Journal of biological chemistry, Vol. 278, Issue 5, pp. 3372-7, (2003) (PubMed).
: "Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms." in: European journal of immunology, Vol. 33, Issue 6, pp. 1642-8, (2003) (PubMed).
Synonyms and alternative names related to SIGLEC7
sialic acid-binding Ig-like lectin 7 (LOC468976), sialic acid binding Ig like lectin 7 (SIGLEC7), AIRM1, CD328, CDw328, D-siglec, p75, p75/AIRM1, QA79, SIGLEC-7, SIGLEC7, SIGLEC19P, SIGLECP2Protein level used designations for SIGLEC7
- sialic acid binding Ig-like lectin 7
- AIRM-1
- QA79 membrane protein
- adhesion inhibitory receptor molecule 1, siglec-7
- sialic acid binding immunoglobulin-like lectin 7
- sialic acid-binding Ig-like lectin 7
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