SIGLEC12 Products
(Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))
Categories
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
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Featured SIGLEC12 Categories
SIGLEC12 Antibodies
High quality antibodies with extensive validation data.
SIGLEC12 ELISA Kits
Reliable ELISA kits for a wide range of species.
SIGLEC12 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SIGLEC12 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN529939
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (2)
Cat. No.
ABIN7437041
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, ELISA
Validations
- (1)
Cat. No.
ABIN7169557
Quantity
100 μL
Datasheet
Datasheet
Recommended SIGLEC12 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN511596
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rabbit
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN775684
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Guinea Pig
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN777649
Quantity
96 tests
Datasheet
Datasheet
Recommended SIGLEC12 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319989
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319987
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319985
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our SIGLEC12 products
: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, (2003) (PubMed).: "Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs." in: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 23816-24, (2001) (PubMed).
: "A second uniquely human mutation affecting sialic acid biology." in: The Journal of biological chemistry, Vol. 276, Issue 43, pp. 40282-7, (2001) (PubMed).
Synonyms and alternative names related to SIGLEC12
sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), sialic acid binding Ig like lectin 12 (SIGLEC12), sialic acid binding Ig-like lectin 12 (SIGLEC12), S2V, Siglec-XII, SIGLECL1, SLGProtein level used designations for SIGLEC12
- SIGLEC-like 1
- sialic acid-binding Ig-like lectin 12
- sialic acid-binding Ig-like lectin-like 1
- sialic acid binding immunoglobulin-like lectin-like protein 1
- sialic acid-binding lectin Siglec-L1
- siglec-12
- siglec-L1
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