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SIGLEC12 Products

(Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))

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Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

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Featured SIGLEC12 Categories

SIGLEC12 Antibodies

High quality antibodies with extensive validation data.

SIGLEC12 ELISA Kits

Reliable ELISA kits for a wide range of species.

SIGLEC12 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SIGLEC12 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN529939
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (2)
Cat. No. ABIN7437041
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA
Validations
  • (1)
Cat. No. ABIN7169557
Quantity 100 μL
Datasheet Datasheet

Recommended SIGLEC12 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN511596
Quantity 96 tests
Datasheet Datasheet
Reactivity Rabbit
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN775684
Quantity 96 tests
Datasheet Datasheet
Reactivity Guinea Pig
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN777649
Quantity 96 tests
Datasheet Datasheet

Recommended SIGLEC12 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1319989
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1319987
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1319985
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our SIGLEC12 products

Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, (2003) (PubMed).

Yu, Lai, Maoui, Banville, Shen: "Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs." in: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 23816-24, (2001) (PubMed).

Angata, Varki, Varki: "A second uniquely human mutation affecting sialic acid biology." in: The Journal of biological chemistry, Vol. 276, Issue 43, pp. 40282-7, (2001) (PubMed).

Synonyms and alternative names related to SIGLEC12

sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), sialic acid binding Ig like lectin 12 (SIGLEC12), sialic acid binding Ig-like lectin 12 (SIGLEC12), S2V, Siglec-XII, SIGLECL1, SLG

Protein level used designations for SIGLEC12

  • SIGLEC-like 1
  • sialic acid-binding Ig-like lectin 12
  • sialic acid-binding Ig-like lectin-like 1
  • sialic acid binding immunoglobulin-like lectin-like protein 1
  • sialic acid-binding lectin Siglec-L1
  • siglec-12
  • siglec-L1
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