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SIGIRR Products

(Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))

Categories

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity).

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Featured SIGIRR Categories

SIGIRR Antibodies

High quality antibodies with extensive validation data.

SIGIRR ELISA Kits

Reliable ELISA kits for a wide range of species.

SIGIRR Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SIGIRR Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7437203
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (7)
Cat. No. ABIN7437206
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN7169723
Quantity 100 μL
Datasheet Datasheet

Recommended SIGIRR ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4884521
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6386238
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6730776
Quantity 96 tests
Datasheet Datasheet

Recommended SIGIRR Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1319981
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7198052
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN7504527
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our SIGIRR products

ONeill, Fitzgerald, Bowie: "The Toll-IL-1 receptor adaptor family grows to five members." in: Trends in immunology, Vol. 24, Issue 6, pp. 286-90, (2003) (PubMed).

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, (2003) (PubMed).

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, (2002) (PubMed).

Synonyms and alternative names related to SIGIRR

single Ig and TIR domain containing (SIGIRR), single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr), single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (sigirr), single Ig and TIR domain containing (Sigirr), AI256711, RGD1306732, sc:d148, TIR8

Protein level used designations for SIGIRR

  • single Ig IL-1-related receptor
  • single Ig IL-1R-related molecule
  • single immunoglobulin domain IL1R1 related
  • single immunoglobulin domain-containing IL1R-related protein
  • toll/interleukin-1 receptor 8
  • single Ig IL-1 receptor related protein
  • single Ig IL-1R-related protein
  • TIR8
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