SIAH1B Proteins
(Seven in Absentia 1B (SIAH1B))
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Confers constitutive instability to HIPK2 through proteasomal degradation. Probably triggers the ubiquitin- mediated degradation of many substrates. Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S- nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (By similarity).
antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.
Recommended SIAH1B Proteins
Synonyms and alternative names related to SIAH1B
seven in absentia 1B (Siah1b), AA960570, Sinh1bProtein level used designations for SIAH1B
- E3 ubiquitin-protein ligase SIAH1B
- drosophila seven-in-absentia gene product homolog
- seven in absentia homolog 1b
- siah-1b
You are here:
